Ovary tumor
Brenner tumors
Benign Brenner tumor

Authors: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 27 May 2016, last major update December 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: ovarian benign Brenner tumor
Cite this page: Benign Brenner tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorb9brenner.html. Accessed July 23rd, 2018.
Definition / general
  • Derived from ovarian surface epithelium and metaplasia; similar to Walthard nests
  • 6% bilateral
Gross description
  • Unilateral, firm, white / yellow
  • Resembles fibroma / thecoma except for cystic areas with yellow-brown fluid
Gross images

Images hosted on PathOut server:

Sharply demarcated

Fibroma-like appearance

Solid fibroma-like component and two cysts

Images hosted on other servers:

Infarcted tumor

Firm, yellowish white

Microscopic (histologic) description
  • Solid and cystic nests of urothelium-like cells surrounded by abundant dense, fibrous stroma
  • Epithelial cells have sharp outlines
  • Cells are uniform, polygonal with pale cytoplasm, small but distinct nucleoli, often grooved nuclei (similar to granulosa cell tumors)
  • Frequent microcysts within epithelial nests
  • Metaplastic: with prominent cystic formation, accompanied by florid mucinous changes similar to cystitis glandularis
  • Proliferating: with papillary pattern and low grade nuclear atypia resembling low grade urothelial carcinoma of bladder (some authors consider this type of Brenner tumor to be borderline, Cancer 1985;56:582)
Microscopic (histologic) images

Images hosted on PathOut server:

Fibromatous stromal component

Resembling coffee beans

Several lumens

Mucinous epithelium

Ciliated epithelium

Images hosted on other servers:

"Coffee-bean" appearance

With Ossification


Solid and cystic nests

Transitional epithelial cells

Nests of transitional cells

Irregular nests

With mucinous cystadenoma


Brenner tumor
Positive stains
Negative stains
  • CK20