Ovary tumor
Brenner tumors
Borderline Brenner tumor

Topic Completed: 1 December 2012

Revised: 8 February 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: ovarian borderline Brenner tumor

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Cite this page: Ehdaivand S Borderline Brenner tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorborderlinebrenner.html. Accessed February 17th, 2020.
Definition / general
  • Mean age 60 years, older than for benign Brenner tumor
  • Larger tumor with mass related symptoms
  • May be associated with bladder urothelial carcinoma
  • Rare local recurrence, otherwise benign behavior
Gross description
  • Unilateral, multilocular cysts, 10 - 25 cm with papillary or polypoid projection into lumen
Gross images

Polypoid mass

Microscopic (histologic) description
  • Solid and papillary epithelial proliferation with moderate to high grade nuclear atypia
  • Papillary areas lined by multilayer epithelium (looks like high grade urothelial carcinoma), cells have prominent nucleoli, nuclear grooves, no stromal invasion
Microscopic (histologic) images

Papillae protrude into lumen

Well-differentiated transitional cells

With high grade transitional cell carcinoma

Positive stains
Negative stains
  • CK20
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