Ovary tumor
Brenner tumors
Borderline Brenner tumor

Authors: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 7 August 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: ovarian borderline Brenner tumor
Page views in 2018: 2,965
Page views in 2019 to date: 121
Cite this page: Ehdaivand, S. Borderline Brenner tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorborderlinebrenner.html. Accessed January 17th, 2019.
Definition / general
  • Mean age 60 years, older than for benign Brenner tumor
  • Larger tumor with mass related symptoms
  • May be associated with bladder urothelial carcinoma
  • Rare local recurrence, otherwise benign behavior
Gross description
  • Unilateral, multilocular cysts, 10 - 25 cm with papillary or polypoid projection into lumen
Gross images

Images hosted on PathOut server:

Polypoid mass

Microscopic (histologic) description
  • Solid and papillary epithelial proliferation with moderate to high grade nuclear atypia
  • Papillary areas lined by multilayer epithelium (looks like high grade urothelial carcinoma), cells have prominent nucleoli, nuclear grooves, no stromal invasion
Microscopic (histologic) images

Images hosted on PathOut server:

Papillae protrude into lumen

Well-differentiated transitional cells

With high grade transitional cell carcinoma

Positive stains
Negative stains
  • CK20