Ovary tumor
Mucinous tumors
Mucinous borderline tumor / atypical proliferative mucinous tumor

Topic Completed: 1 July 2012

Revised: 10 September 2019

Copyright: (c) 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Ovarian mucinous borderline tumor

Related topics: Endocervical, Intestinal

Page views in 2019: 13,881
Page views in 2020 to date: 1,938
Cite this page: Ehdaivand S. Mucinous borderline tumor / atypical proliferative mucinous tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorborderlinemucinous.html. Accessed February 18th, 2020.
Definition / general
  • Also called atypical proliferative mucinous tumor of ovary or mucinous ovarian tumor of low malignant potential
  • 85% are intestinal type; 15% are endocervical type
  • 5% of intestinal type are bilateral; 30-40% of endocervial type are bilateral (Cancer 1988;61:340)
  • Pure borderline tumors and borderline tumors with intraepithelial carcinoma or microinvasion are almost always Stage I and clinically benign, but must sample tumor extensively to rule out more extensive invasion (Am J Surg Pathol 2002;26:139)
  • High stage borderline tumors with abdominal cavity mucin may represent ovarian metastases rather than primary borderline tumors - must examine appendix to correctly interpret
Prognostic factors
  • 10 year survival: stage I - 95% (better than previously thought; prior series may have included metastases from intestine and pancreas); noninvasive malignant - 90% (Am J Surg Pathol 2000;24:1447)
Microscopic (histologic) description
  • Intestinal type:
    • Resemble dysplastic intestinal epithelium with goblet cells, neuroendocrine cells and occasional Paneth cells
    • Neoplastic cells have hyperchromasia, crowding, increased mitosis, stratification forming papillae with thin fibrous cores
    • Lumens contain mucin
    • Stroma may have a brisk inflammatory reaction with histocytes and large areas of necrosis

  • Endocervical type:
    • Contain broad papillae lined by benign appearing stratified mucinous and eosinophilic endocervical-like cells
    • Brisk neutrophilic response
    • Intraepithelial carcinoma and microinvasion are rare

  • Classification:
    1. Borderline with atypia: grade 1 nuclei and papillae with cords
    2. Borderline with intraepithelial carcinoma: grade 2/3 nuclei, 4+ layers or cribriform or stroma-free papillary growth pattern
    3. Borderline with microinvasion: invasive glands usually accompanied by desmoplastic reaction
Microscopic (histologic) images

Images hosted on PathOut server:

Mucinous cystic tumor with intraepithelial carcinoma

Molecular / cytogenetics description
Back to top