Brenner tumors
Brenner tumors-overview

Topic Completed: 1 December 2012

Minor changes: 19 October 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed search: Brenner tumor[title] ovarian

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Cite this page: Ehdaivand S Brenner tumors-overview. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorbrennergen.html. Accessed October 20th, 2020.
Definition / general
  • One of two types of transitional cell tumors - also transitional cell carcinoma
  • 1 - 2% of ovarian neoplasms
  • Usually age 40+; median age 50 years
  • Slow growth, rarely ascites
  • Adenofibromas in which epithelial component consists of sharply demarcated nests of urothelial-like cells
  • Associated with hyperestrinism (endometrial hyperplasia and uterine bleeding), mucinous cystadenoma, struma ovarii, urothelial carcinoma of bladder
  • Has true urothelial differentiation based on immunostains (Am J Surg Pathol 2003;27:1434)
  • Epidermoid cysts may originate from epithelial cell nests of Brenner tumor (Am J Clin Pathol 1980;73:272)
Case reports
Negative stains
  • p16, p53
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