Ovary tumor
Brenner tumors
General

Authors: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 27 May 2016, last major update December 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: Brenner tumor[title] ovarian
Definition / General
  • One of two types of transitional cell tumors - also transitional cell carcinoma
  • 1 - 2% of ovarian neoplasms
  • Usually age 40+; median age 50 years
  • Slow growth, rarely ascites
  • Adenofibromas in which epithelial component consists of sharply demarcated nests of urothelial-like cells
  • Associated with hyperestrinism (endometrial hyperplasia and uterine bleeding), mucinous cystadenoma, struma ovarii, urothelial carcinoma of bladder
  • Has true urothelial differentiation based on immunostains (Am J Surg Pathol 2003;27:1434)
  • Epidermoid cysts may originate from epithelial cell nests of Brenner tumor (Am J Clin Pathol 1980;73:272)
Case Reports
Negative Stains
  • p16, p53