Ovary tumor
Other surface epithelial tumors
Clear cell adenocarcinoma

Authors: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 29 Augus 2016, last major update July 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: Ovarian clear cell adenocarcinoma

Related topics: Oxyphilic variant
Cite this page: Clear cell adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorclearcell.html. Accessed March 19th, 2018.
Definition / general
  • Also called mesonephroid adenocarcinoma
  • Associated with endometriosis or endometrioid carcinoma of the ovary
  • Usually ages 40 - 59 years
  • Stage for stage, similar prognosis to other ovarian carcinomas
Gross description
  • Spongy, cystic
Gross images
Images hosted on PathOut server, courtesy of Ayse Ayhan, M.D.:

Clear cell carcinoma, case 1


Outer appearance

Cut surface

Fixed pictures of surgical material

Clear cell carcinoma, case 2

Outer appearance

Cut surface

Fixed cut surface

Other images hosted on PathOut server:

Polypoid tumor
arising in endometriotic cyst

Microscopic (histologic) description
  • Tubular-cystic, papillary or solid
  • Papillary cores have prominent hyalinization
  • Large tumor cells, some with nuclei that protrude into lumina (hobnail), clear cytoplasm (glycogen, mucin, fat)
  • Resembles mucinous tumor on frozen section
Microscopic (histologic) images

Scroll to see all images.

Images hosted on PathOut server:

Clear cell and endometrioid adenocarcinoma, mixed

Papillary pattern

Hobnail and flat cells

Left: cystic pattern; right: lined by moderately atypical hobnail cells

Solid pattern

Papillae lined by hobnail cells and have hyalinized cores

Targetoid appearance

Mucicarmine stain

Poorly differentiated

Complex glomeruloid papilla

With adenofibroma component

With extensive round cell infiltration

Numerous intracytoplasmic hyaline bodies

Images hosted on other servers:

Various images

Contributed by Dr. Semir Vranic

H&E and HNF-1beta expression

Positive stains
Negative stains
  • AFP, WT1, ER, usually GPC3
Differential diagnosis