Ovary tumor
Other tumors not specific to ovary
Fibromatosis

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 29 June 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Fibromatosis [title] ovary
Definition / General
  • First defined by Young and Scully in 1984 (Int J Gynecol Pathol 1984;3:153) as tumorlike ovarian enlargement due to diffuse ovarian fibrosis, caused by non neoplastic proliferation of undifferentiated ovarian stroma
Epidemiology
Sites
  • Abdominal or extraabdominal
Pathophysiology
  • Local tissue injury activates platelets and macrophages, which release growth factors that stimulates fibroblastic proliferation around follicle
  • May represent burnt out stage of massive ovarian edema (Surgical Pathology of the Ovaries - pgs. 147-54)
Clinical Features
  • Menstrual abnormalities, abdominal pain
  • Rarely hirsutism or virilization
Laboratory
  • Normal: CA125, CEA, CA19-9, AFP
Radiology Description
  • Ultrasonography: intrapelvic solid tumors including cystic areas
  • CT: hyperdense (to myometrium), homogenous, solid and variably enhancing solid ovarian mass
  • MRI: Hypointense lobulated ovarian masses (Gynecol Oncol 2004;94:223)
Case Reports
Treatment
  • Salpingo-oophorectomy
Clinical Images

Images hosted on other servers:

Ovarian fibromatosis

Bilateral heterogeneously echogenic ovarian masses

Slightly hyperattenuating

Poor enhancement of masses

Low signal intensity

Bilateral adnexal masses

Gross Description
  • Solid ovarian mass 8-14 cm in diameter
  • Cut surface is grey-white, solid
Gross Images

Images hosted on other servers:

Left ovarian mass

Micro Description
  • Fibromatoid proliferation of collagen producing spindle cell with follicles entrapped within the lesion
Differential Diagnosis