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Ovary tumor
Sex cord stromal tumors
Granulosa cell tumor - juvenile

Reviewer: Shahrzad Ehdaivand, M.D. (see Reviewers page)
Revised: 3 June 2014, last major update December 2012
Copyright: (c) 2002-2014, PathologyOutlines.com, Inc.

General
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Case reports
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Treatment
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Gross description
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Gross images
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Various images



Contributed by Dr. Hanni Gulwani, New Delhi (India) - 3 year old girl with breast enlargement:

Mostly solid tumor with focal cystic change

Micro description
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Micro images
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Gross, H&E and inhibin

Solid cellular neoplasm with focal follicle formation

Solid nodules


Papillary pattern

Lumen of follicles stained by mucicarmine

Theca cells


Mitotic figures

Hobnail nuclei

Severe nuclear atypia


Case of Week #59:

Various images



Contributed by Dr. Hanni Gulwani, New Delhi (India) - 3 year old girl with breast enlargement:

Primordial follicles in normal ovary

Poorly formed follicles with mucoid secretions

Well-demarcated tumor with pseudolobular pattern
and compressed normal ovary at periphery


Compact spindle cell areas with hemangiopericytoma like pattern

Loose edematous areas with abortive follicles


Spindle cells are SMA+

Vimentin+;

High MIB-1 expression

ER+ and PR+


Positive stains
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Negative stains
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Molecular description
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Differential diagnosis
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End of Ovary tumor > Sex cord stromal tumors > Granulosa cell tumor - juvenile


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