Ovary tumor
Other tumors not specific to ovary
Granulocytic sarcoma

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 29 June 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Granulocytic sarcoma [title] ovary
Cite this page: Granulocytic sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorgranulocyticsarcoma.html. Accessed December 6th, 2016.
Definition / General
  • Extramedullary tumor of malignant myeloid precursor cells (also called nonleukemic granulocytic sarcoma)
  • Can arise de novo or be the sole manifestation of relapse
  • Also called chloroma due to green color imparted by myeloperoxidase in myelogenous leukemic cells (Eur J Radiol 2012;81:472)
Sites
Clinical Features
Radiology Description
  • Mixed cystic and solid adnexal mass with intermediate signal intensity on T1 weighted images and hypointensity on T2 weighted images (Br J Radiol 1999;72:301)
Radiology Images

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Homogenous pelvic mass

Prognostic Factors
Case Reports
Treatment
  • Surgery followed by induction chemotherapy (daunorubicin / cytosine arabinoside) followed by three cycles of consolidation chemotherapy (cytosine arabinoside)
Gross Description
  • Lobulated solid / cystic mass 5-10 cm
  • Outer surface encapsulated and cut surface is tan grey with multiple small hemorrhagic and brownish areas
Gross Images

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Acute leukemia



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Lobulated solid mass of ovary

Encapsulated lesion with green areas

Micro Description
  • Monomorphic population of small round cells diffusely infiltrating ovarian stroma
  • Discohesive cells lying in sheets
  • Cells have scant to moderate basophilic cytoplasm; are hyperchromatic, with high nuclear cytoplasmic ratio, coarse chromatin, conspicuous nucleoli
Micro Images

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Thin cords



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H&E

H&E

Myeloperoxidase, CD45, alkaline phosphatase, vimentin

Myeloperoxidase, lysozyme

Cytology Description
  • Large round to oval cells with moderate pale blue cytoplasm, high nuclear / cytoplasmic ratio
  • Nuclei are round to oval with 2-4 prominent nucleoli (blast cells)
  • Few large monocytoid cells with prominent nucleoli
Cytology Images

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FNA breast (fig 2C-2E)