Ovary tumor
Other tumors not specific to ovary
Leiomyoma


Topic Completed: 1 December 2014

Minor changes: 11 March 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: Leiomyoma [title] ovary

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Cite this page: Gupta N. Leiomyoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorleiomyoma.html. Accessed May 30th, 2020.
Definition / general
  • Accounts for 0.5 - 1% of all benign ovarian tumors
  • Associated with synchronous leiomyomas of uterus
  • Do not recur locally or metastasize, even if mitotically active
Epidemiology
Pathophysiology
  • Arises from smooth muscle cells in ovarian hilar blood vessels
  • Other possible origins include cells in ovarian ligament, smooth muscle cells or multipotential cells in ovarian stroma, undifferentiated germ cells, or cortical smooth muscle metaplasia (Am J Surg Pathol 2004;28:1436)
Clinical features
  • Abdominal pain, mass, vaginal discharge
Laboratory
  • CA125, CA19-9 and CEA are within normal range
Radiology description
  • Transvaginal ultrasonography: solid mass
  • MRI T1 and T2 weighted images: well circumscribed low signal intensity mass (Eur Radiol 1998;8:1444)
Case reports
Treatment
  • Surgical resection
Gross description
  • Solid lobulated mass, median 3 cm (range 0.3 - 20 cm), often in hilar region
  • Cut surface is gray-white, whorled
Gross images

AFIP images

Lobulated sectioned surface



Images hosted on other servers:

Gray-white with whorled pattern

Ovary replaced with creamy mass

Microscopic (histologic) description
  • Irregular bundles and whorling of spindle shaped cells with no atypia or pleomorphism
  • Degenerative changes like hyaline degeneration and myxomatous changes can be seen
  • May be cellular, have prominent mitotic activity or occasionally have bizarre nuclei or myxoid stroma
Microscopic (histologic) images

AFIP images

Spindle cells arranged in intersecting fascicles



Images hosted on other servers:

Long fascicle of spindle shaped cells

H&E, desmin, α smooth muscle actin

Positive for SMA

Positive stains
Negative stains
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