Ovary tumor
Sex cord stromal tumors
Leydig cell tumor (hilus cell tumor)

Author: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 14 September 2018, last major update December 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed search: Ovarian Leydig cell tumor
Cite this page: Ehdaivand, S. Leydig cell tumor (hilus cell tumor). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorleydig.html. Accessed October 20th, 2018.
Definition / general
  • Rare, derived from hilar cells
  • Almost always benign
  • Call a nonhilar Leydig cell tumor if it occurs in ovarian cortical stroma
  • Symptoms: virilization, elevated 17-ketosteroid excretion and unresponsive to cortisol suppression
  • Excision
Gross description
  • Unilateral
Gross images

Images hosted on PathOut server:

Red-brown mass

Brown-black nodule

Microscopic (histologic) description
  • Large lipid laden cells with distinct borders; Reinke crystals common
Microscopic (histologic) images

Images hosted on PathOut server:

Crystals of Reinke

Cellular areas separated by anuclear eosinophilic zones

Prominent fibrous stroma

Fibrinoid replacement

Abundant, pale, vacuolated cytoplasm

Enlarged, hyperchromatic, bizarre nuclei