Ovary tumor
Sex cord stromal tumors
Leydig cell tumor (hilus cell tumor)

Topic Completed: 1 December 2012

Revised: 12 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed search: Ovarian Leydig cell tumor

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Cite this page: Ehdaivand S Leydig cell tumor (hilus cell tumor). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorleydig.html. Accessed November 13th, 2019.
Definition / general
  • Rare, derived from hilar cells
  • Almost always benign
  • Call a nonhilar Leydig cell tumor if it occurs in ovarian cortical stroma
  • Symptoms: virilization, elevated 17-ketosteroid excretion and unresponsive to cortisol suppression
  • Excision
Gross description
  • Unilateral
Gross images

Red-brown mass

Brown-black nodule

Microscopic (histologic) description
  • Large lipid laden cells with distinct borders; Reinke crystals common
Microscopic (histologic) images

Crystals of Reinke

Cellular areas separated by anuclear eosinophilic zones

Prominent fibrous stroma

Fibrinoid replacement

Abundant, pale, vacuolated cytoplasm

Enlarged, hyperchromatic, bizarre nuclei

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