Ovary tumor
Sex cord stromal tumors
Leydig cell tumor (hilus cell tumor)

Author: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 7 June 2016, last major update December 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed search: Ovarian Leydig cell tumor
Definition / General
  • Rare, derived from hilar cells
  • Almost always benign
  • Call a nonhilar Leydig cell tumor if it occurs in ovarian cortical stroma
  • Symptoms: virilization, elevated 17-ketosteroid excretion and unresponsive to cortisol suppression
Treatment
  • Excision
Gross Description
  • Unilateral
Gross Images

Images hosted on PathOut server:

Red-brown mass

Brown-black nodule

Micro Description
  • Large lipid laden cells with distinct borders; Reinke crystals common
Micro Images

Images hosted on PathOut server:

Crystals of Reinke

Cellular areas separated by anuclear eosinophilic zones

Prominent fibrous stroma

Fibrinoid replacement

Abundant, pale, vacuolated cytoplasm

Enlarged, hyperchromatic, bizarre nuclei