Sex cord stromal tumors
Leydig cell tumor (hilus cell tumor)

Topic Completed: 1 December 2012

Minor changes: 9 March 2020

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PubMed search: Ovarian Leydig cell tumor

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Cite this page: Ehdaivand S. Leydig cell tumor (hilus cell tumor). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorleydig.html. Accessed September 21st, 2020.
Definition / general
  • Rare, derived from hilar cells
  • Almost always benign
  • Call a nonhilar Leydig cell tumor if it occurs in ovarian cortical stroma
  • Symptoms: virilization, elevated 17-ketosteroid excretion and unresponsive to cortisol suppression
  • Excision
Gross description
  • Unilateral
Gross images

AFIP images

Red-brown mass

Brown-black nodule

Microscopic (histologic) description
  • Large lipid laden cells with distinct borders; Reinke crystals common
Microscopic (histologic) images

AFIP images

Crystals of Reinke

Cellular areas separated by anuclear eosinophilic zones

Prominent fibrous stroma

Fibrinoid replacement

Abundant, pale, vacuolated cytoplasm

Enlarged, hyperchromatic, bizarre nuclei

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