Ovary tumor
Sex cord stromal tumors
Leydig cell tumor (hilus cell tumor)


Topic Completed: 1 December 2012

Revised: 9 March 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed search: Ovarian Leydig cell tumor

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Cite this page: Ehdaivand S. Leydig cell tumor (hilus cell tumor). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorleydig.html. Accessed April 7th, 2020.
Definition / general
  • Rare, derived from hilar cells
  • Almost always benign
  • Call a nonhilar Leydig cell tumor if it occurs in ovarian cortical stroma
  • Symptoms: virilization, elevated 17-ketosteroid excretion and unresponsive to cortisol suppression
Treatment
  • Excision
Gross description
  • Unilateral
Gross images

AFIP images

Red-brown mass

Brown-black nodule

Microscopic (histologic) description
  • Large lipid laden cells with distinct borders; Reinke crystals common
Microscopic (histologic) images

AFIP images

Crystals of Reinke

Cellular areas separated by anuclear eosinophilic zones

Prominent fibrous stroma


Fibrinoid replacement

Abundant, pale, vacuolated cytoplasm

Enlarged, hyperchromatic, bizarre nuclei

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