Table of ContentsDefinition / General | Gross Description | Micro Description | Positive Stains | Electron Microscopy Description | Differential Diagnosis
Cite this page: Lipid (steroid, lipoid) cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorlipid.html. Accessed October 25th, 2016.
Definition / General
- Any age, usually associated with virilizing syndrome (defeminization and amenorrhea)
- Cells either lutein (theca / stroma), hilar (Leydig, with Reinke crystals) or adrenal cortical type
- If Cushing syndrome present, tumor often called "adrenal cortical type"
- Exact origin of tumor is unknown
- May be biologically active or inactive
- Malignant: 25%, usually large (7 cm or more), necrosis, hemorrhage, nuclear atypia, mitoses and may have peritoneal implants
- Usually unilateral, yellow / brown nodules separated by fibrous trabeculae
- Large rounded or polyhedral cells with abundant eosinophilic or vacuolated cytoplasm
- Fat stains on fresh / frozen tissue, vimentin (75%), keratin (50%) and actin (30%)
Electron Microscopy Description
- Increased smooth endoplasmic reticulum, mitochondria have tubulovesicular cristae
- Tumors with secondary proliferation of steroid hormone-producing cells: stromal luteoma, luteinized granulosa cell tumor (usually juvenile), fibroma-thecoma, stromal Leydig cell tumor and proliferations at periphery of other tumors