Ovary tumor
Other tumors not specific to ovary
Lymphoma

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 5 July 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Lymphoma [title] ovary
Definition / General
  • Can be primary or secondary
  • Arises from hilar lymphoid tissue or ovarian teratoma
Clinical Features
Diagnosis
  • Fox et al. proposed 3 criteria for the diagnosis of primary ovarian lymphoma (Br J Obstet Gynaecol 1988;95:386):
    1. Confined to ovarian regional lymph nodes or adjunctive organs at diagnosis
    2. NO abnormal cells in bone marrow or peripheral blood, and
    3. Any extraovarian disease must occur at least a few months after the appearance of the ovarian lesions
Laboratory
  • Normal serum CEA, CA125, CA19–9
Radiology Description
Radiology Images

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Abdominopelvic tumor

Prognostic Factors
  • Histologic type is most important prognostic factor
  • B cell tumors associated with longer survival (Gynecol Oncol 2003;90:215)
Case Reports
Treatment
  • Based on histology, type, and clinical staging
  • Surgery, chemotherapy (CHOP or Rituxan-CHOP) or radiotherapy
Gross Description
  • Mostly unilateral
  • Microscopic to 15 cm
  • Solid whitish fleshy mass
Gross Images

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Diffuse large B cell lymphoma

Burkitt's lymphoma

Lobulation and cream color



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Bilateral ovarian tumors

Primary ovarian lymphoma

Micro Description
  • Burkitt lymphoma tends to grow in cords or nests forming pseudoacini, accompanied by sclerosis and resembling carcinoma
  • Diffuse large cell lymphoma may appear as short fascicles and form interlacing bundles of spindle cells, resembling a stromal tumor; has diffuse pattern of tumor cells with large vesicular nuclei and prominent nucleoli
Micro Images


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Cords arrangement

Nests

Alveolar pattern

Case of Week #295

CD20

Ki-67



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Follicular lymphoma

Burkitt lymphoma

Pre T lymphoblastic lymphoma



Diffuse large B cell lymphoma:

Large cell lymphoma

Monotonous medium cells

Hyperchromatic nuclei

Diffuse growth pattern


H&E, CD20 (fig 3), CD3 (fig 4)

CD20

LCA

Negative for PLAP

Cytology Images

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Diffuse large B cell lymphoma (COW #295)

Positive Stains
  • Burkitt lymphoma: CD20 and bcl6
  • Diffuse large B cell lymphoma: CD45/LCL, CD20, bcl6, variable CD10 and bcl2
  • Follicular lymphoma: CD20, bcl6, CD10
  • Anaplastic large T cell lymphoma: CD3, CD10, CD30, CD43, CD99, TdT; negative for ALK1 and bcl6
  • PreT lymphoblastic lymphoma: CD3, CD10, CD99, TdT; negative for bcl6
Negative Stains
Differential Diagnosis