Brenner tumors
Malignant Brenner tumor

Topic Completed: 1 December 2012

Minor changes: 31 May 2020

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PubMed Search: ovarian malignant Brenner tumor

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Cite this page: Ehdaivand S. Malignant Brenner tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumormalignantbrenner.html. Accessed September 24th, 2020.
Definition / general
  • Atypical cytology and stromal invasion
  • May be bilateral
  • Better prognosis than urothelial (transitional cell) carcinoma
Gross images

AFIP images

Soft tan areas with small cysts, firm white areas

Solid nodules

Microscopic (histologic) description
  • Resembles urothelial, squamous or undifferentiated carcinoma, but associated with benign or borderline Brenner component; stromal invasion is present
Microscopic (histologic) images

AFIP images

Malignant transitional cells invade cyst wall

Two benign Brenner nests

Early squamous differentiation

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