Ovary tumor
Other tumors not specific to ovary
Ovary tumor - Mesothelioma

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 5 July 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Mesothelioma [title] ovary
Definition / General
  • Primary ovarian malignant mesotheliomas (POMM) are a rare, aggressive neoplasm of mesothelial cells, with poor prognosis
  • Patients usually present with widespread peritoneal tumor, but occasionally involvement is limited to 1-2 ovaries
  • Needs to be differentiated from secondary ovarian involvement by peritoneal malignant mesothelioma
Epidemiology
  • Median age 52 years, range 16 to 63 years
Sites
  • Peritoneum, pericardium, tunica vaginalis
Etiology
  • Asbestos exposure, prior radiotherapy
Clinical Features
Laboratory
Case Reports
  • 50 year old woman with simultaneous occurrence of well differentiated papillary mesothelioma and endometrioid ovarian cancer (Gynecol Oncol Case Rep 2013;4:53)
Treatment
  • Surgery with / without chemotherapy or radiotherapy
Gross Description
  • 3 to 15 cm, usually bilateral
  • Solid with small cysts
Gross Images

Images hosted on Pathout server:

Solid mural nodule and tumor on cyst lining

Micro Description
  • Epithelial or biphasic tumor with papillary, tubular-glandular or solid patterns with features of malignancy
  • Tumor cells have moderate atypia and low mitotic rate
  • Stroma is hyalinized, occasionally with striking hyalinized cores and psammoma bodies
Micro Images

Images hosted on Pathout server:

Solid and tubulopapillary patterns

Surface of ovary



Images hosted on other servers:

Well differentiated papillary tumor

Biphasic tumor

Calretinin+

Positive Stains
Negative Stains
Differential Diagnosis