Mucinous tumors
Mucinous tumors-overview

Topic Completed: 1 July 2012

Minor changes: 19 October 2020

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PubMed search: Ovarian mucinous tumors

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Cite this page: Ehdaivand S. Mucinous tumors-overview. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumormucinous.html. Accessed November 26th, 2020.
Definition / general
  • Most / all epithelial cells contain mucin
  • Can resemble endocervical, gastric, intestinal type epithelium
  • Second most frequent epithelial tumor after serous
  • 15% of ovarian neoplasms, rare before puberty or after menopause, more common in teenagers and young adults
  • 80% are benign, 10% are borderline and 10% are carcinoma
  • May be associated with mature cystic teratoma (Am J Surg Pathol 2007;31:854)

  • Relationship with appendiceal tumors:
    • Based on genetic analysis, some ovarian and appendiceal lesions are independent, others are related

    • Features favoring appendiceal (non-ovarian) origin:
      • Ovarian surface involvement only
      • Signet ring cell differentiation with appendiceal tumor identified (current or prior) of similar morphology, bilateral tumor consistent with appendiceal or colonic primary, unilateral tumor consistent with appendiceal or colonic primary with a history of appendiceal or colonic adenocarcinoma
      • Normal / only slightly enlarged ovaries, bilateral ovarian involvement, simple or focally proliferative mucinous epithelium with abundant extracellular mucin in cases with predominantly surface involvement of the ovaries
      • Multifocal or extensive abdominal cavity mucin in cases with stromal involvement, ruptured appendiceal adenoma and unruptured ovarian tumor of similar histology
      • Presence of an associated mucinous intestinal tumor (Hum Pathol 1995;26:509)
      • Pseudomyxoma peritonei is almost always associated with a low grade appendiceal primary
Gross description
  • Compared to serous neoplasms, have more cysts, larger size (up to 25 kg), more often unilateral, fibromas rare
  • Smooth outer surface with variable solid areas
  • Filled with sticky, gelatinous fluid rich in glycoproteins
Positive stains
Negative stains
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