Ovary tumor
Mucinous tumors
"Sarcoma-like" mural nodules

Authors: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 20 May 2016, last major update July 2012

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PubMed search: Ovarian mural nodules sarcoma-like

Related topics: General, Sarcomatous, Anaplastic carcinoma foci
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Cite this page: Sarcoma-like mural nodules. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumormuralnodulessarcoma.html. Accessed October 20th, 2019.
Definition / general
  • Usually young women (mean 39-47 years old)
  • Considered benign or reactive
  • Excellent prognosis; presence does not affect outcome
Gross description
  • Typically multiple, small (0.6 to 6 cm), discrete, sharply demarcated, red-brown
Microscopic (histologic) description
  • Well circumscribed with hemorrhage and necrosis but no vascular invasion
  • Variations:
    • Pleomorphic and epulis-like: composed of heterogeneous cell population including numerous multinucleated osteoclast-like giant cells, atypical spindle cells with prominent mitotic activity and inflammatory cells
    • Pleomorphic and spindle cell: consisting predominantly of atypical spindle cells with large, hyperchromatic nuclei, prominent nucleoli, frequent atypical mitotic figures, mixed with histiocytes and inflammatory cells
    • Giant cell-histiocytic: composed of regular, round, well differentiated mononucleated giant cells with ground glass cytoplasm
Microscopic (histologic) images

Images hosted on PathOut server:

Cellular nodule is well demarcated

Osteoclast-like giant cells and smaller mononuclear cells

Positive stains
  • Vimentin, CD68
Negative stains
  • Keratin (may be a few scattered keratin+ cells)
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