Ovary tumor
Other tumors not specific to ovary
Myofibroblastoma

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 5 July 2016, last major update March 2015

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Myofibroblastoma [title] ovary
Definition / General
Terminology
  • Myogenic stromal tumor
  • At other sites, may be called atypical variant of leiomyoma
Epidemiology
  • 22 year old woman in single case report from ovary
  • Also at sites along anatomic "milk-line" that extends from axilla to medial groin, including breast, soft tissue of abdomen, back, buttock, groin/inguinal region, cervix, vaginal wall
Etiology
Radiology Description
Treatment
  • Local excision; does not recur
Clinical Images

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Breast myofibroblastoma

Gross Description
  • Large mass up to 9.0 cm, entirely replacing ovary (in single case report)
Gross Images

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Myofibroblastoma of buttock

Micro Description
  • Unencapsulated but well circumscribed
  • Bland spindled cells arranged into various patterns, similar to solitary fibrous tumor and hemangiopericytoma
  • Also unusual morphologic variants (with atypical cells, epithelioid, myxoid with or without atypical cells, lipomatous, deciduoid-like)
Micro Images

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Breast

Negative Stains
Electron Microscopy Images
  • Variable admixture of undifferentiated mesenchymal cells, fibroblasts, myofibroblasts and smooth muscle cells
  • Generally, myofibroblasts are represented by cells rich in organelles (rough endoplasmatic reticulum, Golgi complexes) and containing bundles of myofilaments forming focal densities (Pathol Res Pract 1999;195:1)
Molecular / Cytogenetics Description
Differential Diagnosis