Ovary tumor
Other tumors not specific to ovary
Neuroendocrine carcinoma (non small cell type)

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 6 July 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Neuroendocrine carcinoma [title] ovary
Cite this page: Neuroendocrine carcinoma (non small cell type). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorneuroendocrinecarcinoma.html. Accessed November 15th, 2018.
Definition / general
  • Neuroendocrine carcinoma (NEC) can be small cell (SCNEC) [hypercalcemic or pulmonary] or non small cell type (NSCNEC)
  • NSCNEC are rare and aggressive
  • Typically admixed with other surface epithelial and germ cell neoplasms
  • Tend to present at advanced stage and cause death within a mean of 17 months after diagnosis (Am J Surg Pathol 2007;31:774)
Clinical features
Radiology description
Prognostic factors
Case reports
  • Combination of surgical resection (TAHBSO) and etoposide/platinum chemotherapy has been employed (Gynecol Oncol 2011;122:190)
  • Patients with stage III/IV disease often die of disease
Gross description
  • Mostly unilateral, cystic, or solid/cystic
  • Median 16 cm, range 5 to 26 cm (Am J Surg Pathol 2007;31:774)
  • Can be associated with other epithelial neoplasm - mucinous neoplasms, endometrioid carcinoma, mixed endometrioid and mucinous carcinoma, high grade carcinoma not otherwise specified
Gross images

Images hosted on other servers:

Bilateral ovarian masses

Microscopic (histologic) description
  • Solid pattern, nests or trabeculae of large or intermediate oval to round cells
  • Brisk mitotic activity, areas of necrosis and single cell necrosis also seen
Microscopic (histologic) images

Images hosted on PathOut server:

Nests and trabeculae


Images hosted on other servers:

Prominent nucleoli

Synaptophysin, pan-cytokeratin, mucicarmine


Positive stains
Negative stains
Electron microscopy description
  • Neurosecretory granules
Differential diagnosis