Ovary tumor
Other tumors not specific to ovary
Neuroendocrine carcinoma (nonsmall cell type)

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 6 July 2016, last major update December 2014

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PubMed Search: Neuroendocrine carcinoma [title] ovary
Cite this page: Neuroendocrine carcinoma (nonsmall cell type). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorneuroendocrinecarcinoma.html. Accessed March 26th, 2017.
Definition / General
  • Neuroendocrine carcinoma (NEC) can be small cell (SCNEC) [hypercalcemic or pulmonary] or non small cell type (NSCNEC)
  • NSCNEC are rare and aggressive
  • Typically admixed with other surface epithelial and germ cell neoplasms
  • Tend to present at advanced stage and cause death within a mean of 17 months after diagnosis (Am J Surg Pathol 2007;31:774)
Clinical Features
Radiology Description
Prognostic Factors
Case Reports
  • Combination of surgical resection (TAHBSO) and etoposide/platinum chemotherapy has been employed (Gynecol Oncol 2011;122:190)
  • Patients with stage III/IV disease often die of disease
Gross Description
  • Mostly unilateral, cystic, or solid/cystic
  • Median 16 cm, range 5 to 26 cm (Am J Surg Pathol 2007;31:774)
  • Can be associated with other epithelial neoplasm - mucinous neoplasms, endometrioid carcinoma, mixed endometrioid and mucinous carcinoma, high grade carcinoma not otherwise specified
Gross Images

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Bilateral ovarian masses

Micro Description
  • Solid pattern, nests or trabeculae of large or intermediate oval to round cells
  • Brisk mitotic activity, areas of necrosis and single cell necrosis also seen
Micro Images

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Nests and trabeculae


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Prominent nucleoli

Synaptophysin, pan-cytokeratin, mucicarmine


Positive Stains
Negative Stains
Electron Microscopy Description
  • Neurosecretory granules
Differential Diagnosis