Ovary tumor
Other tumors not specific to ovary
Osteoclast-like giant cell tumor

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 6 July 2016, last major update December 2014

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PubMed Search: Osteoclast-like giant cell tumor of ovary
Cite this page: Osteoclast-like giant cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorosteoclastlike.html. Accessed October 26th, 2016.
Definition / General
  • Peculiar microscopic picture of round or spindle shaped mononucleated stromal cells admixed with multinucleated giant cells
  • Likely represents a reactive lesion of mesenchymal ovarian stromal cells stimulated by substances in associated tumor or cyst, with monocytic / macrophage origin (Cancer 1993;71:1751)
  • Mostly associated with mucinous cyst, rarely with serous / hemorrhagic cysts
  • Benign clinical course, without recurrence or metastasis (Histol Histopathol 1995;10:55)
Clinical Features
  • Abdominal mass or pelvic pain
Radiology Description
  • USG: solid cystic ovarian mass
Case Reports
  • Surgical: salpingo-oophorectomy
Gross Description
  • Well circumscribed firm mass, 1-4 cm
  • Cut surface is yellow with brown hemorrhage
  • Adjacent ovarian tissue may show unilocular / multilocular cyst
Micro Description
  • Diffuse, bland-appearing osteoclast-like giant cells mixed with pleomorphic mononuclear cells
  • Hemorrhage, large areas of necrosis and frequent mitotic figures among mononuclear cells
  • Infiltrative border, vascular invasion
  • No cystic tumor, no epithelial component
Micro Images

Images hosted on other servers:

Pancreas: osteoclast-like giant cell tumor

Kidney: osteoclast-like giant cell tumor

Cytology Images

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Urothelial carcinoma - Diff Quick

Positive Stains
  • Osteoclast-like giant cells: CD68, vimentin, alpha-1-antichymotrypsin and CD45
  • Mononuclear cells: vimentin, PCNA, actin
Negative Stains
  • Mononuclear cells: keratin, EMA, CK7, CD45, CD68, S100
  • Osteoclastic giant cells: actin
Electron Microscopy Description
  • Giant cells have ruffled border and abundant mitochondria (resemble osteoclasts)
Differential Diagnosis
  • Spindle cell mural nodule: no bone trabeculae; giant cells are keratin positive