Other tumors

Topic Completed: 1 December 2014

Minor changes: 11 March 2020

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PubMed Search: Paraganglioma [title] ovary

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Cite this page: Gupta N. Paraganglioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorparaganglioma.html. Accessed September 30th, 2020.
Definition / general
  • Can be primary or metastatic
  • Primary ovarian paragangliomas are very rare
  • Commonly present with hypertension
  • Potentially aggressive tumors
Clinical features
  • Abdominal discomfort, adnexal mass or hypertension
  • Potentially aggressive - 1 case had extraovarian disease at surgery
Radiology description
  • USG: solid cytic ovarian mass
Case reports
  • Surgery
  • Long term followup is recommended
Gross description
  • Large solid mass (8 - 22 cm) with tan-yellow to brown cut surface
Microscopic (histologic) description
  • Well circumscribed but unencapsulated
  • Closely packed nests of tumor cells in zellballen pattern
  • Polygonal cells with abundant eosinophilic granular cytoplasm and speckled chromatin
  • Mitotic activity is low (0 - 2/10 HPF)
Microscopic (histologic) images

AFIP images

Nests composed of tumor cells


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Mediastinum tumor: H&E and S100

Positive stains
Negative stains
  • EMA, PanCK, Keratin
Electron microscopy description
  • Dense core neurosecretory granules devoid of desmosomes
Differential diagnosis
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