Ovary tumor
Other tumors not specific to ovary
Paraganglioma

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 6 July 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Paraganglioma [title] ovary
Cite this page: Paraganglioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorparaganglioma.html. Accessed December 6th, 2016.
Definition / General
  • Can be primary or metastatic
  • Primary ovarian paragangliomas are very rare
  • Commonly present with hypertension
  • Potentially aggressive tumors
Epidemiology
Sites
Clinical Features
  • Abdominal discomfort, adnexal mass or hypertension
  • Potentially aggressive - 1 case had extraovarian disease at surgery
Radiology Description
  • USG: solid cytic ovarian mass
Case Reports
Treatment
  • Surgery
  • Long term follow up is recommended
Gross Description
  • Large solid mass (8-22 cm) with tan yellow to brown cut surface
Micro Description
  • Well circumscribed but unencapsulated
  • Closely packed nests of tumor cells in zellballen pattern
  • Polygonal cells with abundant eosinophilic granular cytoplasm and speckled chromatin
  • Mitotic activity is low (0-2/10 hpf)
Micro Images

Images hosted on Pathout server:

Nests composed of tumor cells

Chromogranin



Images hosted on other servers:
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Mediastinum tumor: H&E and S100

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Various images, location unknown

Virtual Slides
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Ovarian paraganglioma

Positive Stains
Negative Stains
  • EMA, PanCK, Keratin
Electron Microscopy Description
  • Dense core neurosecretory granules devoid of desmosomes
Differential Diagnosis