Ovary tumor
Other tumors not specific to ovary
Squamous cell carcinoma

Authors: Nalini Gupta, M.D. (see Authors page)

Revised: 7 July 2016, last major update June 2014

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Squamous cell carcinoma [title] ovary
Definition / General
  • Squamous cell carcinoma of ovary can be pure arising denovo or may represent extreme expression of squamous metaplasia in endometriosis, endometrioid carcinomas, transformation of ovarian teratomas and HPV related transformation
  • Pure SCC and those arising from endometriosis are included in surface epithelial tumor by WHO Classification
  • Often associated with dermoid cyst (50%) and endometriosis (20%)
  • SCC arising in dermoid are included in germ cell tumor by WHO (Am J Surg Pathol 1996;20:823)
Epidemiology
  • SCCD (associated with dermoid ): 21-75 (mean, 52) years old
  • SCCE (associated with endometriosis ): 29-70 (mean, 49) years old
  • SCCP (Pure SCC): 27-73 (mean, 56) years old (Am J Surg Pathol 1996;20:823)
Sites
  • Genital and extragenital SCC
Clinical Features
  • Lower abdominal mass
Diagnosis
  • Final diagnosis is by histology
Laboratory
Radiology Description
Prognostic Factors
Case Reports
Treatment
  • Total abdominal hysterectomy, bilateral salpingo-oophorectomy and omentectomy, with additional steps as needed to ensure surgical debulking of all grossly visible disease
  • Role of adjuvant chemo and radiotherapy debatable
  • Few case report noted a response to early pa-clitaxel in combination with a platinum agent (Gynecol Oncol 2000;79:515)
Clinical Images

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Triple tissular mass

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Pelvic solid tumor

Gross Description
  • 6-35 cm
  • Often forming mural nodules with intracavitary protrusion
  • Focal necrosis and hemorrhage
Gross Images

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Gross appearance of tumor

Micro Description
  • Can be well to poorly differentiated
  • Well-differentiated form, SCC will show squa-mous maturation, keratin formation and intracellular bridging
  • Poorly differentiated form, few normal squamous features may be identifiable
Micro Images

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Centrally necrotic cells



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Teratoma

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SCC in situ

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H&E, moderately differentiated SCC

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H&E, microinvasive SCC

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p16+

Positive Stains
  • MA903, p63 and CK5 / 6
Negative Stains
  • CA 125
Differential Diagnosis
  • Metastatic SCC: primary elsewhere especially cervix
  • Squamous metaplasia in endometrioid carcinoma: absence of malignant features