Ovary tumor
Sex cord stromal tumors
Sclerosing stromal tumor


Topic Completed: 1 December 2012

Revised: 12 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed search: Ovarian sclerosing stromal tumor

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Cite this page: Ehdaivand S Sclerosing stromal tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorsclerosingstroma.html. Accessed July 18th, 2019.
Definition / general
  • Rare, benign, resembles fibroma-thecoma but in younger patients
  • Prominent vasculature is associated with vascular endothelial growth factor expression (Am J Surg Pathol 1998;22:83)
Gross images

Centrally white and edematous, yellow at periphery

Numerous cysts

Microscopic (histologic) description
  • Lobular growth pattern of cellular and hypocellular areas composed of dual cell population (collagen producing spindle cells and lipid-containing round / oval cells)
  • Interlobular fibrosis, marked vascularity
Microscopic (histologic) images

Pseudolobular pattern

Vacuolated cells resemble signet-ring cells

Prominent thin-walled vessels within nodules

Dilated vessels resemble a hemangiopericytoma

Positive stains
  • Desmin, smooth muscle actin
Molecular / cytogenetics description
  • Trisomy 12 by FISH
Electron microscopy description
  • Luteinized theca-like cells, spindle-shaped fibroblastic cells and primitive mesenchymal cells
Differential diagnosis
Additional references
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