Ovary tumor
Sex cord stromal tumors
Sclerosing stromal tumor

Authors: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 8 June 2016, last major update December 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed search: Ovarian sclerosing stromal tumor
Definition / General
  • Rare, benign, resembles fibroma-thecoma but in younger patients
  • Prominent vasculature is associated with vascular endothelial growth factor expression (Am J Surg Pathol 1998;22:83)
Gross Images

Images hosted on PathOut server:

Centrally white and edematous, yellow at periphery

Numerous cysts

Micro Description
  • Lobular growth pattern of cellular and hypocellular areas composed of dual cell population (collagen producing spindle cells and lipid-containing round / oval cells)
  • Interlobular fibrosis, marked vascularity
Micro Images

Images hosted on PathOut server:

Pseudolobular pattern

Vacuolated cells resemble signet-ring cells

Prominent thin-walled vessels within nodules

Dilated vessels resemble a hemangiopericytoma

Positive Stains
  • Desmin, smooth muscle actin
Molecular / Cytogenetics Description
  • Trisomy 12 by FISH
Electron Microscopy Description
  • Luteinized theca-like cells, spindle-shaped fibroblastic cells and primitive mesenchymal cells
Differential Diagnosis
Additional References