Ovary tumor
Serous tumors
Serous surface tumor


Authors: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 19 May 2016, last major update June 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: serous surface tumor
Definition / General
  • Grows exophytically on ovarian surface, with little involvement of underlying organ
  • Either surface papilloma, surface borderline papillary tumor, serous surface papillary adenocarcinoma
  • Malignant tumors tend to be bilateral, aggressive, have widespread dissemination to peritoneum at presentation
  • May develop in women with family history of ovarian cancer even after prophylactic oophorectomy
Gross Images

Images hosted on PathOut server:

External surface covered by large polypoid excrescences and small granular papillae

Some polypoid excrescences are edematous, resembling vesicles

Small, hemorrhagic, polypoid excrescences

Micro Description
  • Features of typical serous carcinoma
  • Contiguous with hyperplastic mesothelium of ovarian surface or other locations
  • Confined to ovarian surface or with focal minimal invasion
Micro Images

Images hosted on PathOut server:

High grade ovarian carcinoma

Exophytic proliferation of cellular papillae and slit-like glandular spaces

Positive Stains
  • Neutral or acidic mucins (Hum Pathol 1990;21:99), keratin, EMA, B72.3 (85%), LeuM1 (45%), vimentin (35%), CEA (25%)
Electron Microscopy Description
Molecular / Cytogenetics Description
Differential Diagnosis