Ovary tumor
Sex cord stromal tumors
Sertoli cell tumor

Author: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 11 July 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Sertoli cell tumor[title]

Related topics: Lipid rich variant
Definition / General
  • Rare; excellent prognosis
  • Mean age 30 years old, range 2-76 years
  • Tends to secrete estrogen / progesterone, but diagnose based on morphology, not hormones
  • Similar to a well differentiated Sertoli-Leydig tumor without a Leydig component; may have abundant cytoplasmic lipid
  • Associated with Peutz-Jeghers syndrome
  • Usually stage I and clinically benign (Am J Surg Pathol 2005;29:143)
Case Reports
Gross Description
  • Lobulated, solid, yellow-brown, unilateral, mean 9 cm and up to 30 cm
Gross Images

Images hosted on Pathout server:

Yellow and lobulated

Micro Description
  • Closely packed solid or hollow tubules lined by well-differentiated cuboidal to columnar epithelial cells
  • Few or no Leydig cells, often fibromatous or sclerotic; may have amyloid-like material
  • Other patterns include cord-like and diffuse; variable stroma
  • Occasional cells with bizarre nuclei; minimal mitoses, minimal atypia
  • Malignant: moderate to severe cytologic atypia and 5+ MF/10 HPF
Micro Images

Images hosted on Pathout server:

Hollow tubules

Solid tubules

Oxyphilic cell type



Images hosted on other servers:
Missing Image

Fig 1: CT scan
Fig 2A: tubules separated by stroma
Fig 3A: cells arranged in cords and aggregates

Positive Stains
  • Inhibin, vimentin, CD99, CD10, AE1-3 or CAM5.2 (usually), calretinin (50%), variable smooth muscle actin and S100
Negative Stains
  • EMA, chromogranin
Electron Microscopy Description
  • Tight junctions, desmosomes, abundant rough endoplasmic reticulum and lipid
Differential Diagnosis