Ovary tumor
Sex cord stromal tumors
General

Authors: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 3 June 2016, last major update December 2012

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PubMed search: Ovarian sex cord stromal tumor
Cite this page: Sex cord stromal tumors - general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorsexcordgeneral.html. Accessed December 4th, 2016.
Definition / General
  • 5% of ovarian neoplasms, 7% of malignant ovarian neoplasms
  • Derived from ovarian stroma, itself derived from sex cords of embryonic gonad (predecessor of Sertoli, Leydig, granulosa and theca cells)
  • Theca cells produce estrogens; Leydig cells produce androgens
  • Morphology and clinically evident hormonal activity may go together, but classify based on morphology
Positive Stains
Negative Stains
  • EMA, PLAP and CEA
  • Note: anti-Mullerian hormone staining is present in only a small percentage of granulosa or Sertoli tumor cells, but is specific for these tumors (Hum Pathol 2000;31:1202), particularly compared to endometrioid tumors (Hum Pathol 1998;29:840)
  • Strong alpha-inhibin staining is relatively specific for ovarian sex-cord stromal proliferations, although luteinized cells from other tumors are also immunoreactiveb (Hum Pathol 1997;28:1387, Am J Surg Pathol 1997;21:583)