Sex cord-stromal tumors - general
Reviewer: Shahrzad Ehdaivand, M.D. (see Reviewers page)
Revised: 15 October 2013, last major update December 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- 5% of ovarian neoplasms, 7% of malignant ovarian neoplasms
- Derived from ovarian stroma, itself derived from sex cords of embryonic gonad (predecessor of Sertoli, Leydig, granulosa and theca cells)
- Theca cells produce estrogens; Leydig cells produce androgens
- Morphology and clinically evident hormonal activity may go together, but classify based on morphology
- EMA, PLAP and CEA
- Note: anti-Mullerian hormone staining is present in only a small percentage of granulosa or Sertoli tumor cells, but is specific for these tumors (Hum Pathol 2000;31:1202), particularly compared to endometrioid tumors (Hum Pathol 1998;29:840)
- Strong alpha-inhibin staining is relatively specific for ovarian sex-cord stromal proliferations, although luteinized cells from other tumors are also immunoreactiveb (Hum Pathol 1997;28:1387, Am J Surg Pathol 1997;21:583)
End of Ovary tumor > Sex cord-stromal tumors - general
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