Ovary - tumor
Other surface epithelial tumors
Urothelial carcinoma (transitional cell carcinoma)

Author: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 21 June 2016, last major update December 2012

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PubMed Search: Ovary urothelial carcinoma

Cite this page: Urothelial carcinoma (transitional cell carcinoma) . PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorurothelialCA.html. Accessed April 21st, 2018.
Definition / general
  • Note: urothelial carcinoma of the ovary is now considered to represent a poorly differentiated form of high grade serous or endometrioid adenocarcinoma, and not be a distinct entity (Am J Surg Pathol 2013;37:1091)
  • 1-2% of surface epithelial tumors of ovary
  • Mean age 56 years, range 33-94 years
  • Resembles urothelial carcinoma of bladder but no coexisting Brenner component
  • Poorer prognosis than malignant Brenner tumor
  • Median survival for stage 3/4 disease is 28 months, similar to serous carcinoma (Hum Pathol 1996;27:12671)
Gross description
  • Mean 10 cm, range 3-30 cm, 60% solid and cystic, 41% bilateral
Microscopic (histologic) description
  • Undulating, diffuse, insular or trabecular patterns
  • Papillary structures lined by urothelium-like cells and nests of epithelial cells with high grade features, pale granular cytoplasm, large nucleoli or longitudinal grooves, separated by fibrous stroma
  • Usually necrosis
  • May have other ovarian epithelial components (usually serous)
Microscopic (histologic) images
Images hosted on PathOut server:

Grade 3

Various images

Images hosted on other servers:

Fig 5: H&E
Fig 6: ER+

Variety of patterns

Resembles urinary tract tumor

High-grade morphology