Ovary tumor
General
WHO classification of ovarian neoplasms


Topic Completed: 1 May 2012

Revised: 7 February 2019

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PubMed Search: WHO Classification of ovarian neoplasms

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Definition / general
Cite this page: Ehdaivand S WHO classification of ovarian neoplasms. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorwhoclassif.html. Accessed November 13th, 2019.
Definition / general
  • The World Health Organization Histological Classification for ovarian tumors separates ovarian neoplasms according to the most probable tissue of origin: surface epithelial (65%), germ cell (15%), sex cord-stromal (10%), metastases (5%), miscellaneous
  • Surface epithelial tumors are further classified by cell type (serous, mucinous, endometrioid, etc) and atypia (benign, borderline [atypical proliferation, low malignant potential] or malignant; malignant may be invasive or non-invasive)
  • Most malignant tumors are surface epithelial (90%)

  • Surface epithelial - stromal tumors
    • Serous tumors:
      • Benign (cystadenoma)
      • Borderline tumors (serous borderline tumor)
      • Malignant (serous adenocarcinoma)

    • Mucinous tumors, endocervical-like and intestinal type:
      • Benign (cystadenoma)
      • Borderline tumors (mucinous borderline tumor)
      • Malignant (mucinous adenocarcinoma)

    • Endometrioid tumors:
      • Benign (cystadenoma)
      • Borderline tumors (endometrioid borderline tumor)
      • Malignant (endometrioid adenocarcinoma)

    • Clear cell tumors:
      • Benign
      • Borderline tumors
      • Malignant (clear cell adenocarcinoma)

    • Transitional cell tumors:
      • Brenner tumor
      • Brenner tumor of borderline malignancy
      • Malignant Brenner tumor
      • Transitional cell carcinoma (non-Brenner type)

    • Epithelial-stromal:
      • Adenosarcoma
      • Carcinosarcoma (formerly mixed Müllerian tumors)

  • Sex cord - stromal tumors
    • Granulosa tumors:
      • Fibromas
      • Fibrothecomas
      • Thecomas

    • Sertoli cell tumors:
      • Leydig cell tumors

    • Sex cord tumor with annular tubules
    • Gynandroblastoma
    • Steroid (lipid) cell tumors

  • Germ cell tumors
    • Teratoma:
      • Immature
      • Mature
      • Solid
      • Cystic (dermoid cyst)

    • Monodermal (e.g., struma ovarii, carcinoid)
    • Dysgerminoma
    • Yolk sac tumor (endodermal sinus tumor)
    • Mixed germ cell tumors

  • Malignant, not otherwise specified
    • Metastatic cancer from nonovarian primary:
      • Colonic, appendiceal
      • Gastric
      • Breast
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