Graft versus host disease (GVHD)

Author: Deepali Jain, M.D. (see Authors page)

Revised: 8 December 2017, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Graft versus host disease GVHD pancreas

Cite this page: Jain, D. Graft versus host disease (GVHD). website. Accessed July 16th, 2018.
Definition / general
  • Identified in autopsies of children with congenital immune deficiencies with GVHD of other organs (Hum Pathol 1994;25:908)
  • To diagnose, must pay careful attention to pancreatic ducts
  • Note: GVHD may occur post pancreas transplant, involving skin and other organs (Transplantation 2006;82:127)
Microscopic (histologic) description
  • Lymphocytes around large to medium ducts, damage to ductal epithelium (focal necrosis, reactive nuclear changes, inspissated secretions in duct lumens) and periductal edema (Histopathology 1989;14:121)