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Pancreas

Other tumors

Inflammatory myofibroblastic tumor


Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 2 December 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Rare tumor (more common in lung), that may constrict bile duct
● Cases with IgG4+ plasma cells perhaps should be classified separately as IgG4 related disorder, since they are distinct entities (Mod Pathol 2011;24:606)

Micro images
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19 year old man with cystic mass and splenic rupture

Micro description
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● Spindled cells, collagen, and variable lymphocytes and plasma cells
● Rarely has prominent eosinophils

Micro images
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Various images


19 year old man with cystic mass and splenic rupture


Loosely arranged spindle cells with admixed collagen bundles and scattered inflammatory infiltrate; proliferation extends into the adjacent fat and focal small lymphoid aggregates are present


Left: bland spindle cells with lymphocytes and plasma cells (arrows), but no mitotic activity; right-smooth muscle actin

Positive stains
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● Smooth muscle actin, vimentin, p53 (Virchows Arch 2006;448:552)
● ALK (70%, Am J Surg Pathol 2009;33:1330)

Negative stains
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● S100, keratin, EBV-LMP, EBER

Differential diagnosis
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● Follicular dendritic cell tumor
● Inflammatory fibrosarcoma

End of Pancreas > Other tumors > Inflammatory myofibroblastic tumor


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