Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Pancreas

Tumors

Acinar cell cystadenocarcinoma


Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 25 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Typically large tumors up to 17 cm containing multiple cysts
● Marked atypia, frequent mitotic activity

Gross description
=========================================================================

● Large multilocular cystic mass with a pseudocapsule and a spongy appearance

Gross images
=========================================================================



7 kg, multiloculated cystic neoplasm of pancreatic tail/body; thick fibrous capsule surrounds mass, cysts contain serous watery fluid, vary from pinpoint to 7 cm; cysts are lined by smooth, white glistening surface; no gross pancreatic tissue is present; tumor attached to, but did not invade spleen (upper right)

Micro description
=========================================================================

● Cysts are lined by a single layer of cuboid/columnar cells
● Cytoplasm has characteristics of acinar cells, with eosinophilic granules in the apex and prominent nucleoli (Hum Pathol 2004;35:1568)

Micro images
=========================================================================


   
Numerous variably sized microcysts

Differential diagnosis
=========================================================================

Acinar cell cystadenoma: no malignant features, no invasion
Acinar cell hyperplasia: common, resembles islets, may have minor atypia, may be pre-malignant
Pancreatic endocrine neoplasm: rare mitoses, no polarization, indistinct nucleoli, amyloid stroma, trabeculae, stippled chromatin, although acinar cell may contain scattered endocrine cells and mixed tumors are common

End of Pancreas > Tumors > Acinar cell cystadenocarcinoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).