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Pancreatic endocrine neoplasms

ACTH-secreting tumors

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 8 December 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Not a WHO diagnosis
● Rare pancreatic endocrine neoplasm producing adrenocorticotrophic hormone (ACTH)
● Causes Cushing syndrome: central obesity, muscle weakness, glucose intolerance, hypertension

Case reports

● 41 year old woman with bilateral ovarian metastases (Int J Gynecol Pathol 2002;21:276)
● 54 year old woman with ACTH secretion only at second relapse (J Clin Endocrinol Metab 2004;89:3731)

Gross images

Spleen, adrenal gland and pancreas with tumor

Micro images

Rounded nests of densely packed cells with mitotic figures

66 year old man with ultrasound guided biopsy: H&E and ACTH antibody

ACTH producing tumor with Cushing's syndrome: moderately differentiated tumor with consistent cellular atypia, solid growth pattern, lymphatic invasion

End of Pancreas > Pancreatic endocrine neoplasms > ACTH-secreting tumors

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