Exocrine tumors / carcinomas
Adenosquamous carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 12 December 2017, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Adenosquamous carcinoma[TI] pancreas

Cite this page: Jain, D. Adenosquamous carcinoma. website. Accessed February 24th, 2018.
Definition / general
Microscopic (histologic) images

Images hosted on PathOut server:

Adenosquamous carcinoma

Squamous components

Mucoepidermoid pattern

Left: CAM5.2; right: CK13

Images hosted on other servers:

Squamous components

Clear cell component

Rhabdoid component

Keratin stains intermediate filaments of rhabdoid cells


45 year old man with acantholytic pattern, osteoclast-like and pleomorphic giant cells

Cytology description
  • Squamous and glandular differentiation, although one component often predominates (Cancer 2003;99:372)
  • Extensive necrosis with dense blue globules, squamous ghosts, anucleate squames, atypical single cells, enlarged pyknotic nuclei
  • Purely squamous tumor may be metastasis or represent undersampling
Cytology images

Images hosted on other servers:

Various images

Positive stains
Differential diagnosis
  • Adenoacanthoma: benign squamous component
  • Squamous cell carcinoma: no glandular component or mucin staining, even after extensive search