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General
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Clinical features
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Diagnosis
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Laboratory
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Case reports
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Treatment
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Gross images
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Tail tumor

Micro description
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Micro images
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Insulin immunostains


Tumor cells stained for insulin with
the immunoperoxidase technique, AFIP


Nonfunctioning insulin-producing
microadenoma in MEN1 patient


Insulinoma with concurrent pancreatic adenocarcinoma


Benign insulinoma, AFIP

Endocrine carcinoma with trabecular and lobular pattern, AFIP

Well differentiated endocrine carcinoma with cellular atypia, AFIP

Amyloid in an insulinoma, AFIP

Positive stains
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Electron microscopy description
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Electron microscopy images
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Left: Tumor contains sufficient number of crystalline for diagnostic identification; right: Insulinoma with
prevalence of round haloed granules of low density, plus occasional crystalloid granules (arrow)

Differential diagnosis
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End of Pancreas > Neuroendocrine neoplasms > Insulinoma (beta cell tumor)



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