Exocrine tumors / carcinomas
Large duct pattern

Topic Completed: 1 August 2012

Revised: 28 January 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: Large duct pattern pancreas

Deepali Jain, M.D.
Page views in 2018: 311
Page views in 2019 to date: 255
Cite this page: Jain D. Large duct pattern. website. Accessed December 8th, 2019.
Definition / general
  • Pattern seen in < 10% of usual ductal adenocarcinoma; similar or slightly better prognosis (Mod Pathol 2012;25:439)
  • Ducts are clustered with irregular jagged contours, may have desmoplastic and myxoid stroma, intraluminal neutrophils and granular debris; usually no cystic change
  • Focal microcystic appearance may be due to marked ectasia of infiltrating neoplastic glands, particularly near duodenal muscularis propria
  • May have papillary pattern (Am J Surg Pathol 2012;36:696)
  • Compared to usual ductal adenocarcinoma: higher % female, higher % in tail
Gross description
  • White, sclerotic mass with numerous microcysts < 1 cm, not detectable radiologically
Differential diagnosis
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