Exocrine tumors / carcinomas
Large duct pattern

Author: Deepali Jain, M.D. (see Authors page)

Revised: 21 August 2018, last major update August 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Large duct pattern pancreas

Cite this page: Jain, D. Large duct pattern. website. Accessed November 15th, 2018.
Definition / general
  • Pattern seen in < 10% of usual ductal adenocarcinoma; similar or slightly better prognosis (Mod Pathol 2012;25:439)
  • Ducts are clustered with irregular jagged contours, may have desmoplastic and myxoid stroma, intraluminal neutrophils and granular debris; usually no cystic change
  • Focal microcystic appearance may be due to marked ectasia of infiltrating neoplastic glands, particularly near duodenal muscularis propria
  • May have papillary pattern (Am J Surg Pathol 2012;36:696)
  • Compared to usual ductal adenocarcinoma: higher % female, higher % in tail
Gross description
  • White, sclerotic mass with numerous microcysts < 1 cm, not detectable radiologically
Differential diagnosis