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Pancreas

Other tumors

Lymphoma

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 2 December 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Primary disease is rare (<200 cases reported); may originate in peripancreatic or retroperitoneal lymph nodes
● Biopsy required for diagnosis and to avoid resection, which is not required (BMC Cancer 2006;6:117)
● Only diffuse large B cell lymphoma is included in WHO classification

Clinical features
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● Usually in elderly
● Diffuse large B-cell lymphoma is most common (Am J Clin Pathol 2012;137:414, Diagn Cytopathol 2012;40:732)
● Present with abdominal pain and jaundice due to common bile duct obstruction or abdominal masses

Case reports
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● 58 year old man with follicular lymphoma invading pancreas from adjacent lymph node (JOP 2007;8:44)
● 65 year old woman with advanced angiocentric T cell lymphoma (peripheral T cell lymphoma, NOS) of pancreas and eye presenting as advanced diabetes mellitus with diabetic retinopathy (Hum Pathol 2001;32:741)

Clinical images
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Intraoperative findings of follicular lymphoma. a-tumor of head of pancreas; b/c-enucleation procedure for tumo; d-view after tumor enucleation

Gross images
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Follcular lymphoma

Micro images
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Angiocentric T cell lymphoma: A-pancreas is heavily infiltrated by lymphoma, with only some residual ducts and islets; B-tumor cells almost replace islet

     

     
Diffuse large B cell lymphoma

   
Diffuse large B cell lymphoma-65 year old man


Follcular lymphoma: a/b-central necrosis (H&E and CD20); c/d-proliferating follicules (H&E and CD20)

End of Pancreas > Other tumors > Lymphoma

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