Pancreas
Other tumors
Lymphoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 2 January 2018, last major update August 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Lymphoma[TI] pancreas[TI]

Cite this page: Jain, D. Lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pancreaslymphoma.html. Accessed August 17th, 2018.
Definition / general
  • Primary disease is rare (< 200 cases reported); may originate in peripancreatic or retroperitoneal lymph nodes
  • Biopsy required for diagnosis and to avoid resection, which is not required (BMC Cancer 2006;6:117)
  • Only diffuse large B cell lymphoma is included in WHO classification
Clinical features
Case reports
  • 58 year old man with follicular lymphoma invading pancreas from adjacent lymph node (JOP 2007;8:44)
  • 65 year old woman with advanced angiocentric T cell lymphoma (peripheral T cell lymphoma, NOS) of pancreas and eye presenting as advanced diabetes mellitus with diabetic retinopathy (Hum Pathol 2001;32:741)
Clinical images

Images hosted on other servers:

Intraoperative findings of follicular
lymphoma; a: tumor of head of pancreas;
b / c: enucleation procedure for tumor;
d: view after tumor enucleation

Gross images

Images hosted on other servers:

Follcular lymphoma

Microscopic (histologic) images

Images hosted on other servers:

Angiocentric T cell lymphoma; A: pancreas
is heavily infiltrated by lymphoma,
with only some residual ducts and islets;
B: tumor cells almost replace islet

Follcular lymphoma;
a / b: central necrosis (H&E and CD20);
c / d: proliferating follicules (H&E and CD20)


Diffuse large B cell lymphoma


Diffuse large B cell lymphoma

Diffuse large B cell lymphoma - 65 year old man