Exocrine tumors / carcinomas
Medullary carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 15 December 2017, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Medullary carcinoma pancreas

Cite this page: Jain, D. Medullary carcinoma. website. Accessed October 24th, 2018.
Definition / general
Gross description
  • Soft (since minimal desmoplastic stroma)
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on other servers:

Various images

A: extensive necrosis;
B: poorly differentiated
tumor with syncytial
growth pattern

A: nuclear staining for MLH1;
B: loss of expression of MSH2;
C: loss of expression of MSH6

Molecular / cytogenetics description
  • Usually no KRAS mutations but 20% have inactivation of DNA mismatch repair system