Mucinous nonneoplastic cyst (MNC)

Author: Deepali Jain, M.D. (see Authors page)

Revised: 12 December 2017, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Mucinous nonneoplastic cyst pancreas

Cite this page: Jain, D. Mucinous nonneoplastic cyst (MNC). website. Accessed October 24th, 2018.
Definition / general
Gross description
  • Usually unifocal, head of pancreas, thin walled cysts that don't communicate with ductal system
Gross images

Images hosted on other servers:

Unilocuar and multilocular
cysts with no definitive
connection to pancreatic duct

Microscopic (histologic) description
  • Cuboidal / columnar mucin producing cells with small amount of dense fibrous stroma
  • No ovarian type stroma
  • No cellular atypia or increased proliferation
  • No communication with duct or biliary system
Microscopic (histologic) images

Images hosted on other servers:

Various images

Cytology description
  • Cuboidal / columnar cells in flat honeycomb sheets / nests (100%) with delicate / vacuolated (61%) cytoplasm, round / oval nuclei are small to slightly enlarged with 1 - 2 inconspicuous nucleoli, fine granular chromatin, smooth nuclear contour; also nuclear grooves (43.5%), nuclear pseudoinclusions (26%); usually thin mucin (Pancreas 2013;42:27)
Cytology images

Images hosted on other servers:

Comparison with IPMN

Positive stains
Negative stains
Differential diagnosis