Mucinous nonneoplastic cyst (MNC)

Topic Completed: 1 August 2012

Revised: 25 January 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: Mucinous nonneoplastic cyst pancreas

Deepali Jain, M.D.
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Page views in 2019 to date: 1,585
Cite this page: Jain D. Mucinous nonneoplastic cyst (MNC). website. Accessed December 6th, 2019.
Definition / general
Gross description
  • Usually unifocal, head of pancreas, thin walled cysts that don't communicate with ductal system
Gross images

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Unilocuar and multilocular
cysts with no definitive
connection to pancreatic duct

Microscopic (histologic) description
  • Cuboidal / columnar mucin producing cells with small amount of dense fibrous stroma
  • No ovarian type stroma
  • No cellular atypia or increased proliferation
  • No communication with duct or biliary system
Microscopic (histologic) images

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Various images

Cytology description
  • Cuboidal / columnar cells in flat honeycomb sheets / nests (100%) with delicate / vacuolated (61%) cytoplasm, round / oval nuclei are small to slightly enlarged with 1 - 2 inconspicuous nucleoli, fine granular chromatin, smooth nuclear contour; also nuclear grooves (43.5%), nuclear pseudoinclusions (26%); usually thin mucin (Pancreas 2013;42:27)
Cytology images

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Comparison with IPMN

Positive stains
Negative stains
Differential diagnosis
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