Neuroendocrine neoplasms
Neuroendocrine carcinoma, NOS

Author: Deepali Jain, M.D. (see Authors page)

Revised: 7 June 2017, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Neuroendocrine carcinoma, NOS

Adveritsement: Neuroendocrine Cancer Trial
Cite this page: Neuroendocrine carcinoma, NOS. website. Accessed October 18th, 2017.
Definition / general
  • Poorly differentiated, high grade malignant neoplasm, composed of small, intermediate or large cells, variable organoid features resembling neutroendocrine tumor, diffusely expressing neuroendocrine markers (diffuse staining for synaptophysin; faint or focal staining for chromogranin A), with marked nuclear atypia, multifocal necrosis and a high number of mitoses ( > 20 per 10 HPF) (WHO)
  • High grade (G3) is defined by proliferation fraction and histology
  • Includes small cell carcinoma, large cell (neuro) endocrine carcinoma, poorly differentiated (neuro) endocrine carcinoma
  • Genetically dissimilar from well differentiated neuroendocrine tumors (Am J Surg Pathol 2012;36:173)
Clinical features
  • Represents less than 3% of pancreatic neuroendocrine tumors
  • May produce ACTH
  • Associated with hypercalcemia
Case reports
Gross images

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Small cell carcinoma

Microscopic (histologic) images

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Focal necrosis, AFIP

Small Cell Carcinoma

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Various images

Cytology images

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Metastatic pulmonary small cell carcinoma to pancreas

Differential diagnosis