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Pancreas

Other tumors

Phyllodes tumor


Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 6 December 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Similar to breast tumor; metastases much more likely than pancreas primary

Case reports
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● First primary case reported was 37 year old man (Virchows Arch 2010;456:587)

Micro description
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● Cyst walls lined with a monolayer of non-atypical tall columnar epithelial cells
● Solid areas show storiform proliferation of spindle cells with round, oval or elongated nuclei; also abundant collagen fibers
● Solid areas send phylloid projections into the cystic spaces and main pancreatic duct

Micro images
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Case report: a-main pancreatic duct is filled with tumor; b-solid parts of lesion send phylloid projections into cystic spaces; c-margins between tumor and pancreatic tissues are well demarcated; d-small blood vessels are embedded in solid areas

Cytology images
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Metastatic tumor to pancreas - stromal cells show cytological atypia, with nuclear enlargement, irregular chromatin, irregular nuclear membrane

Positive stains
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● Diffusely positive for alpha-smooth muscle actin, desmin, h-caldesmon

Electron microscopy description
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● Well-developed myofilaments with dense bodies, pinocytic vesicles, basal lumina

Differential diagnosis
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● Gastrointestinal stromal tumor
Inflammatory myofibroblastic tumor
● Leiomyoma
● Leiomyosarcoma
Schwannoma
● Solitary fibrous tumor

End of Pancreas > Other tumors > Phyllodes tumor


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