Pancreas
Neuroendocrine neoplasms
Pancreatic polypeptide secreting tumors

Author: Deepali Jain, M.D. (see Authors page)

Revised: 22 December 2017, last major update August 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Pancreatic polypeptide secreting tumors

Cite this page: Jain, D. Pancreatic polypeptide secreting tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pancreasppoma.html. Accessed August 20th, 2018.
Definition / general
  • Rare endocrine neoplasm with high proportion of pancreatic polypeptide (PP) cells, which typically are more frequent in posterior head of pancreas (from ventral bud)
  • Not a WHO diagnosis
  • Asymptomatic despite high levels of the hormone in plasma
  • Note: PP cells are common in pancreatic endocrine tumors of other types
Case reports
Gross images

Images hosted on other servers:

Various images

Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Endocrine tumor with trabecular pattern

Pancreatic nonfunctioning endocrine tumor



Images hosted on other servers:

A: PPoma showing abundance of PP immunoreactive cells (in black);
B: predominance of PP immunoreactive cells

Electron microscopy images

Images hosted on other servers:

Abundant basal accumulation of secretory granules

Differential diagnosis