Exocrine tumors / carcinomas
Tumors with rhabdoid features

Topic Completed: 1 August 2012

Minor changes: 9 March 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Rhabdoid features pancreas

Deepali Jain, M.D.
Page views in 2019: 732
Page views in 2020 to date: 309
Cite this page: Jain D. Tumors with rhabdoid features. website. Accessed May 28th, 2020.
Definition / general
  • Nonspecific feature of neuroendocrine tumors (Am J Surg Pathol 2003;27:642) and carcinomas, indicative of aggressive behavior
  • This is now a WHO subtype
Case reports
Microscopic (histologic) description
  • Sheets of monotonous tumor cells with abundant densely eosinophilic cytoplasmic inclusions that displace the nuclei toward the periphery, uniform round nuclei, dispersed chromatin
  • Rhabdoid elements merge with conventional areas
  • Suggested that some cases be termed "with cytokeratin aggresomes" (J Clin Pathol 2004;57:1106)
Microscopic (histologic) images

Images hosted on other servers:

Squamous cell carcinoma with rhabdoid phenotype and osteoclast-like giant cells

Adenosquamous carcinoma with rhabdoid features; left: large cells with abundant eosinophilic cytoplasm with paranuclear aggregation of filaments, eccentric nuclei and prominent nucleoli; right: cytokeratin stain highlights cytoplasmic aggregation of intermediate filaments

Authors described as "cytokeratin aggresomes," not rhabdoid

Positive stains
Electron microscopy description
  • Cytoplasmic inclusions are composed of large whorls of intermediate filaments
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