Pancreas
Exocrine tumors / carcinomas
Tumors with rhabdoid features


Topic Completed: 1 August 2012

Revised: 29 January 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Rhabdoid features pancreas

Deepali Jain, M.D.
Page views in 2018: 543
Page views in 2019 to date: 452
Cite this page: Jain D. Tumors with rhabdoid features. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pancreasrhabdoid.html. Accessed August 23rd, 2019.
Definition / general
  • Nonspecific feature of neuroendocrine tumors (Am J Surg Pathol 2003;27:642) and carcinomas, indicative of aggressive behavior
  • Not a WHO diagnosis
Case reports
Microscopic (histologic) description
  • Sheets of monotonous tumor cells with abundant densely eosinophilic cytoplasmic inclusions that displace the nuclei toward the periphery, uniform round nuclei, dispersed chromatin
  • Rhabdoid elements merge with conventional areas
  • Suggested that some cases be termed "with cytokeratin aggresomes" (J Clin Pathol 2004;57:1106)
Microscopic (histologic) images

Images hosted on other servers:
 

Squamous cell carcinoma with rhabdoid phenotype and osteoclast-like giant cells

Adenosquamous carcinoma with rhabdoid features; left: large cells with abundant eosinophilic cytoplasm with paranuclear aggregation of filaments, eccentric nuclei and prominent nucleoli; right: cytokeratin stain highlights cytoplasmic aggregation of intermediate filaments


Authors described as "cytokeratin aggresomes," not rhabdoid

Positive stains
Electron microscopy description
  • Cytoplasmic inclusions are composed of large whorls of intermediate filaments
Back to top