Signet ring cell carcinoma
Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 28 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Extremely rare, usually aggressive, poorly differentiated invasive adenocarcinoma with malignant glandular cells having nucleui pressed to one side by intracytoplasmic mucin (WHO)
● Must exclude breast or GI primary
● 30 year old man (Ultrastruct Pathol 1998;22:147)
● Poorly cohesive epithelial cells containing intracytoplasmic mucin that displaces nuclei towards periphery
● Infiltrates as single cells; variable extracellular mucin
● Resembles mammary lobular carcinoma and gastric carcinoma with targetoid pattern, signet ring cells, linear infiltration
Strands of relatively small tumor cells with many signet-ring cells
Typical signet-ring cells
End of Pancreas > Exocrine tumors > Signet ring cell carcinoma
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