Exocrine tumors / carcinomas
Signet ring cell carcinoma

Topic Completed: 1 August 2012

Minor changes: 9 March 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Signet ring cell carcinoma[TIAB] pancreas

Deepali Jain, M.D.
Page views in 2019: 903
Page views in 2020 to date: 415
Cite this page: Jain D. Signet ring cell carcinoma. website. Accessed May 30th, 2020.
Definition / general
Case reports
Microscopic (histologic) description
  • Poorly cohesive epithelial cells containing intracytoplasmic mucin that displaces nuclei towards periphery
  • Infiltrates as single cells; variable extracellular mucin
  • Resembles mammary lobular carcinoma and gastric carcinoma with targetoid pattern, signet ring cells, linear infiltration
Microscopic (histologic) images


Strands of relatively
small tumor cells
with many signet
ring cells

Typical signet ring cells

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