Exocrine tumors / carcinomas
Signet ring cell carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 15 December 2017, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Signet ring cell carcinoma[TIAB] pancreas

Cite this page: Jain, D. Signet ring cell carcinoma. website. Accessed October 23rd, 2018.
Definition / general
Case reports
Microscopic (histologic) description
  • Poorly cohesive epithelial cells containing intracytoplasmic mucin that displaces nuclei towards periphery
  • Infiltrates as single cells; variable extracellular mucin
  • Resembles mammary lobular carcinoma and gastric carcinoma with targetoid pattern, signet ring cells, linear infiltration
Microscopic (histologic) images

Images hosted on PathOut server:

Strands of relatively
small tumor cells
with many signet
ring cells

Typical signet ring cells