Pancreas
Other tumors
Intraductal tubular adenoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 2 January 2018, last major update August 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Intraductal tubular adenoma pancreas

Cite this page: Jain, D. Intraductal tubular adenoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pancreastubularadenoma.html. Accessed February 19th, 2018.
Definition / general
Gross description
  • Polypoid mass
Gross images

Images hosted on other servers:

Solid tumor (carcinoma)
occupying main
pancreatic duct
with retention cyst

Microscopic (histologic) description
  • Well demarcated nodule composed of closely packed tubular glands lined by columnar, mucin secreting cells with abundant clear cytoplasm and basally oriented nuclei
  • Focal mild atypia present
  • Pyloric metaplasia and focal papillary hyperplasia present in adjacent ductal epithelium
  • Adjacent pancreas may show intraductal papillary mucinous adenoma
Microscopic (histologic) images

Images hosted on other servers:

Intraductal tubular neoplasm has closely
packed glands resembling pyloric glands
of stomach, lined by cuboidal to columnar
cells with round nuclei and small nucleoli

Densely packed tubular glands without mucin pooling

Tumor cells proliferating
in tubular fashion
with irregular
glandular arrangement



Gallbladder lesions:

Tubular glands lined by columnar cells
with abundant mucin containing
cytoplasm and basal nuclei;
cystically dilated gland is also seen

Cells with abundant
eosinophilic cytoplasm
similar to Warthin tumor
of salivary glands

A: squamoid morule;
B: cells with clear biotin
containing nuclei similar to
endometrium of pregnancy


With high grade / dysplasia carcinoma in
situ; closely packed glands lined by cells
with large vesicular nuclei and prominent
nucleoli; mitotic figures were present

MUC6+

CDX2+

Positive stains
Molecular / cytogenetics description