Other tumors
Intraductal tubular adenoma

Topic Completed: 1 August 2012

Revised: 31 January 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: Intraductal tubular adenoma pancreas

Deepali Jain, M.D.
Page views in 2019: 472
Page views in 2020 to date: 232
Cite this page: Jain D. Intraductal tubular adenoma. website. Accessed May 26th, 2020.
Definition / general
Gross description
  • Polypoid mass
Gross images

Images hosted on other servers:

Solid tumor (carcinoma)
occupying main
pancreatic duct
with retention cyst

Microscopic (histologic) description
  • Well demarcated nodule composed of closely packed tubular glands lined by columnar, mucin secreting cells with abundant clear cytoplasm and basally oriented nuclei
  • Focal mild atypia present
  • Pyloric metaplasia and focal papillary hyperplasia present in adjacent ductal epithelium
  • Adjacent pancreas may show intraductal papillary mucinous adenoma
Microscopic (histologic) images

Images hosted on other servers:

Intraductal tubular neoplasm has closely
packed glands resembling pyloric glands
of stomach, lined by cuboidal to columnar
cells with round nuclei and small nucleoli

Densely packed tubular glands without mucin pooling

Tumor cells proliferating
in tubular fashion
with irregular
glandular arrangement

Gallbladder lesions:

Tubular glands lined by columnar cells
with abundant mucin containing
cytoplasm and basal nuclei;
cystically dilated gland is also seen

Cells with abundant
eosinophilic cytoplasm
similar to Warthin tumor
of salivary glands

A: squamoid morule;
B: cells with clear biotin
containing nuclei similar to
endometrium of pregnancy

With high grade / dysplasia carcinoma in
situ; closely packed glands lined by cells
with large vesicular nuclei and prominent
nucleoli; mitotic figures were present



Positive stains
Molecular / cytogenetics description
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