Pancreas
General
WHO classification
Author: Raul S. Gonzalez, M.D.
Editor-in-Chief: Debra L. Zynger, M.D.
Last author update: 10 December 2020
Last staff update: 8 April 2021
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PubMed Search: WHO classification[TIAB] pancreas[TI]
Cite this page: Gonzalez RS. WHO classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/pancreaswho.html. Accessed April 18th, 2024.
Definition / general
- WHO classification of tumors of the pancreas
- Currently on 5th edition, published in 2019
- Based on histologic appearance, not molecular characteristics
WHO (2019)
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Benign epithelial tumors and precursors ICD-O codes
- Serous cystadenoma, NOS 8441/0
- Macrocystic (oligocystic) serous cystadenoma
- Solid serous adenoma
- Von Hippel-Lindau syndrome associated serous cystic neoplasm
- Mixed serous-neuroendocrine neoplasm
- Serous cystadenocarcinoma, NOS 8441/3
- Glandular intraepithelial neoplasia, low grade 8148/0
- Glandular intraepithelial neoplasia, high grade 8148/2
- Intraductal papillary mucinous neoplasm with low grade intraepithelial neoplasia 8453/0
- Intraductal papillary mucinous neoplasm with high grade intraepithelial neoplasia 8453/2
- Intraductal papillary mucinous neoplasm with associated invasive carcinoma 8453/3
- Intraductal oncocytic papillary neoplasm, NOS 8455/2
- Intraductal oncocytic papillary neoplasm with associated invasive carcinoma 8455/3
- Intraductal tubulopapillary neoplasm 8503/2
- Intraductal tubulopapillary neoplasm with associated invasive carcinoma 8503/3
- Mucinous cystic neoplasm with low grade intraepithelial neoplasia 8470/0
- Mucinous cystic neoplasm with high grade intraepithelial neoplasia 8470/2
- Mucinous cystic neoplasm with associated invasive carcinoma 8470/3
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Malignant epithelial tumors ICD-O codes
- Duct adenocarcinoma, NOS 8500/3
- Colloid carcinoma 8480/3
- Poorly cohesive carcinoma 8490/3
- Signet ring cell carcinoma 8490/3
- Medullary carcinoma, NOS 8510/3
- Adenosquamous carcinoma 8560/3
- Epidermoid carcinoma 8576/3
- Large cell carcinoma with rhabdoid phenotype 8014/3
- Carcinoma, undifferentiated, NOS 8020/3
- Undifferentiated carcinoma with osteoclast-like giant cells 8035/3
- Acinar cell carcinoma 8550/3
- Acinar cell cystadenocarcinoma 8551/3
- Mixed acinar-neuroendocrine carcinoma 8154/3
- Mixed acinar-endocrine-ductal carcinoma 8154/3
- Mixed acinar-ductal carcinoma 8552/3
- Pancreatoblastoma 8971/3
- Solid pseudopapillary neoplasm of the pancreas 8452/3
- Solid pseudopapillary neoplasm with high grade dysplasia
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Pancreatic neuroendocrine neoplasms ICD-O codes
- Pancreatic neuroendocrine microadenoma 8150/0
- Neuroendocrine tumor, NOS 8240/3
- Neuroendocrine tumor, grade 1 8240/3
- Neuroendocrine tumor, grade 2 8249/3
- Neuroendocrine tumor, grade 3 8249/3
- Pancreatic neuroendocrine tumor, nonfunctioning 8150/3
- Oncocytic pancreatic neuroendocrine tumor, nonfunctioning
- Pleomorphic pancreatic neuroendocrine tumor, nonfunctioning
- Clear cell pancreatic neuroendocrine tumor, nonfunctioning
- Cystic pancreatic neuroendocrine tumor, nonfunctioning
- Functioning pancreatic neuroendocrine tumors
- Insulinoma 8151/3
- Gastrinoma 8153/3
- VIPoma 8155/3
- Glucagonoma 8152/3
- Somatostatinoma 8156/3
- ACTH producing tumor 8158/3
- Enterochromaffin cell carcinoid 8241/3
- Serotonin producing tumor 8241/3
- Neuroendocrine carcinoma, NOS 8246/3
- Large cell neuroendocrine carcinoma 8013/3
- Small cell neuroendocrine carcinoma 8041/3
- Mixed neuroendocrine - nonneuroendocrine neoplasm (MiNEN) 8154/3
