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Pancreas

Tumors

WHO classification


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 30 November 2012, last major update August 2012
Copyright: (c) 2012, PathologyOutlines.com, Inc.

WHO (2010)
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Epithelial tumors
Benign
  8551/0 Acinar cell cystadenoma
  8441/0 Serous cystadenoma, NOS

Premalignant lesions
  8148/2 Pancreatic intraepithelial neoplasia, grade 3 (PanIN-3)
  8453/0 Intraductal papillary mucinous neoplasm (IPMN) with low- or intermediate-grade dysplasia
  8453/2 Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia
  8503/2 Intraductal tubulopapillary neoplasm (ITPN)
  8470/0 Mucinous cystic neoplasm (MCN) with low- or intermediate-grade dysplasia
  8470/2 Mucinous cystic neoplasm (MCN) with high-grade dysplasia

Malignant lesions
  8500/3 Ductal adenocarcinoma
  8560/3 Adenosquamous carcinoma
  8480/3 Mucinous adenocarcinoma
  8576/3 Hepatoid carcinoma
  8510/3 Medullary carcinoma, NOS
  8490/3 Signet ring cell carcinoma
  8020/3 Undifferentiated carcinoma
  8035/3 Undifferentiated carcinoma with osteoclast-like cells
  8550/3 Acinar cell carcinoma
  8551/3 Acinar cell cystadenocarcinoma
  8453/3 Intraductal papillary mucinous carcinoma (IPMN) with an associated invasive carcinoma
  8552/3 Mixed acinar-ductal carcinoma
  8154/3 Mixed acinar-neuroendocrine carcinoma
  8154/3 Mixed acinar-neuroendocrine-ductal carcinoma
  8154/3 Mixed ductal-neuroendocrine carcinoma
  8470/3 Mucinous cystic neoplasm (MCN) with an associated invasive carcinoma
  8971/3 Pancreatoblastoma
  8441/3 Serous cystadenocarcinoma, NOS
  8452/3 Solid-pseudopapillary neoplasm

Neuroendocrine neoplasms
  8150/0 Pancreatic neuroendocrine microadenoma
  8240/3 Neuroendocrine tumor G1 (NET G1) / Carcinoid
  8249/3 Neuroendocrine tumor G2 (NET G2)
  8246/3 Neuroendocrine carcinoma, NOS
  8013/3 Large cell neuroendocrine carcinoma
  8041/3 Small cell neuroendocrine carcinoma
  8241/3 Enterochromaffin cell (EC), serotonin-producing neuroendocrine tumour (NET)
  8153/3 Gastrinoma, malignant
  8152/3 Glucagonoma, malignant
  8151/3 Insulin producing carcinoma (insulinoma)
  8156/3 Somatostatinoma, malignant
  8155/3 Vipoma, malignant

Mesenchymal tumours
  9170/0 Lymphangioma, NOS
  8850/0 Lipoma, NOS
  8815/1 Solitary fibrous tumor
  9260/3 Ewing sarcoma
  8806/3 Desmoplastic small round cell tumor
  Perivascular epithelioid cell neoplasm

Lymphomas
  9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS

Secondary tumours
  Secondary tumours of the pancreas

References: WHO Classification of Tumours of the Digestive System 2010, PubCan.org, Pathologe 2011;32 Suppl 2:332

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