Pancreas
WHO classification of Tumors
General

Author: Wei Chen, M.D., Ph.D. (see Authors page)

Editorial Board Member review: Andrey Bychkov, M.D., Ph.D. and Raul S. Gonzalez, M.D.

Revised: 23 September 2017, last major update August 2017

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Pancreas tumor "WHO classification"

Cite this page: Chen, W. WHO classification of tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pancreaswho.html. Accessed October 22nd, 2017.
Definition / general
  • WHO classification of tumors of the pancreas
  • Currently on 4th edition, published in 2010
  • Based on histologic appearance, not molecular characteristics
  • Similar classification used in College of American Pathologists protocol for examination of pancreas specimens
WHO 2010 Classification
Epithelial tumors
Benign
  • 8551/0 Acinar cell cystadenoma
  • 8441/0 Serous cystadenoma

Premalignant lesions*
  • 8148/2 Pancreatic intraepithelial neoplasia, grade 3 (PanIN-3)
  • 8453/0 Intraductal papillary mucinous neoplasm (IPMN) with low or intermediate grade dysplasia
  • 8453/2 Intraductal papillary mucinous neoplasm (IPMN) with high grade dysplasia
  • 8503/2 Intraductal tubulopapillary neoplasm (ITPN)
  • 8470/0 Mucinous cystic neoplasm (MCN) with low or intermediate grade dysplasia
  • 8470/2 Mucinous cystic neoplasm (MCN) with high grade dysplasia

Malignant lesions
  • 8500/3 Ductal adenocarcinoma
    • 8560/3 Adenosquamous carcinoma
    • 8480/3 Mucinous adenocarcinoma
    • 8576/3 Hepatoid carcinoma
    • 8510/3 Medullary carcinoma
    • 8490/3 Signet ring cell carcinoma
    • 8020/3 Undifferentiated carcinoma
    • 8035/3 Undifferentiated carcinoma with osteoclast-like cells
  • 8550/3 Acinar cell carcinoma
  • 8551/3 Acinar cell cystadenocarcinoma
  • 8453/3 Intraductal papillary mucinous neoplasm (IPMN) with an associated invasive carcinoma
  • 8552/3 Mixed acinar ductal carcinoma
  • 8154/3 Mixed acinar neuroendocrine carcinoma
  • 8154/3 Mixed acinar neuroendocrine ductal carcinoma
  • 8154/3 Mixed ductal neuroendocrine carcinoma
  • 8470/3 Mucinous cystic neoplasm (MCN) with an associated invasive carcinoma
  • 8971/3 Pancreatoblastoma
  • 8441/3 Serous cystadenocarcinoma
  • 8452/3 Solid pseudopapillary neoplasm

Neoplasms of the neuroendocrine pancreas (updated to the 2017 classification - Lloyd: WHO Classification of Tumours of Endocrine Organs (IARC WHO Classification of Tumours), Fourth Edition, 2017)
  • Nonfunctioning (nonsyndromic) neuroendocrine tumors
    • 8150/0 Pancreatic neuroendocrine microadenoma
    • 8150/3 Non-functioning pancreatic neuroendocrine tumor
  • 8151/3 Insulinoma
  • 8152/3 Glucagonoma
  • 8156/3 Somatostatinoma
  • 8153/3 Gastrinoma
  • 8155/3 VIPoma
  • 8241/3 Serotonin producing tumors with and without carcinoid syndrome
  • 8158/3 ACTH producing tumor with Cushing syndrome
  • 8246/3 Pancreatic neuroendocrine carcinoma (poorly differentiated neuroendocrine neoplasm)
  • 8154/3 Mixed neuroendocrine nonneuroendocrine neoplasms
    • 8154/3 Mixed ductal neuroendocrine carcinoma
    • 8154/3 Mixed acinar neuroendocrine carcinoma

Mature teratoma

Mesenchymal tumors
  • 9170/0 Lymphangioma
  • 8850/0 Lipoma
  • 8815/1 Solitary fibrous tumor
  • Perivascular epithelioid cell neoplasm (PEComa)
  • 9260/3 Ewing sarcoma
  • 8806/3 Desmoplastic small round cell tumor

Lymphomas
  • 9680/3 Diffuse large B cell lymphoma (DLBCL)
  • 9690/3 Follicular lymphoma
  • 9699/3 Lymphoma of mucosa associated lymphoid tissue (MALT lymphoma)
  • T cell lymphomas

Secondary tumors

Note: * According to the Baltimore Consensus Meeting (2015), a two tiered system (low vs. high grade) is proposed for all pancreatic precursor lesions, with the provision that the current intermediate grade dysplasia now be categorized as low grade. High grade dysplasia is to be reserved for only the upper most end of the spectrum ("carcinoma in situ" type lesions).