Pancreas - WHO classification of tumors

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Pancreas

Tumors

WHO classification

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 30 November 2012, last major update August 2012
Copyright: (c) 2012, PathologyOutlines.com, Inc.

WHO (2010)
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Epithelial tumors
Benign
8551/0 Acinar cell cystadenoma
8441/0 Serous cystadenoma, NOS

Premalignant lesions
8148/2 Pancreatic intraepithelial neoplasia, grade 3 (PanIN-3)
8453/0 Intraductal papillary mucinous neoplasm (IPMN) with low- or intermediate-grade dysplasia
8453/2 Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia
8503/2 Intraductal tubulopapillary neoplasm (ITPN)
8470/0 Mucinous cystic neoplasm (MCN) with low- or intermediate-grade dysplasia
8470/2 Mucinous cystic neoplasm (MCN) with high-grade dysplasia

Malignant lesions
8500/3 Ductal adenocarcinoma
8560/3 Adenosquamous carcinoma
8480/3 Mucinous adenocarcinoma
8576/3 Hepatoid carcinoma
8510/3 Medullary carcinoma, NOS
8490/3 Signet ring cell carcinoma
8020/3 Undifferentiated carcinoma
8035/3 Undifferentiated carcinoma with osteoclast-like cells
8550/3 Acinar cell carcinoma
8551/3 Acinar cell cystadenocarcinoma
8453/3 Intraductal papillary mucinous carcinoma (IPMN) with an associated invasive carcinoma
8552/3 Mixed acinar-ductal carcinoma
8154/3 Mixed acinar-neuroendocrine carcinoma
8154/3 Mixed acinar-neuroendocrine-ductal carcinoma
8154/3 Mixed ductal-neuroendocrine carcinoma
8470/3 Mucinous cystic neoplasm (MCN) with an associated invasive carcinoma
8971/3 Pancreatoblastoma
8441/3 Serous cystadenocarcinoma, NOS
8452/3 Solid-pseudopapillary neoplasm

Neuroendocrine neoplasms
8150/0 Pancreatic neuroendocrine microadenoma
8240/3 Neuroendocrine tumor G1 (NET G1) / Carcinoid
8249/3 Neuroendocrine tumor G2 (NET G2)
8246/3 Neuroendocrine carcinoma, NOS
8013/3 Large cell neuroendocrine carcinoma
8041/3 Small cell neuroendocrine carcinoma
8241/3 Enterochromaffin cell (EC), serotonin-producing neuroendocrine tumour (NET)
8153/3 Gastrinoma, malignant
8152/3 Glucagonoma, malignant
8151/3 Insulin producing carcinoma (insulinoma)
8156/3 Somatostatinoma, malignant
8155/3 Vipoma, malignant

Mesenchymal tumours
9170/0 Lymphangioma, NOS
8850/0 Lipoma, NOS
8815/1 Solitary fibrous tumor
9260/3 Ewing sarcoma
8806/3 Desmoplastic small round cell tumor
Perivascular epithelioid cell neoplasm

Lymphomas
9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS

Secondary tumours
Secondary tumours of the pancreas

● References: WHO Classification of Tumours of the Digestive System 2010, PubCan.org, Pathologe 2011;32 Suppl 2:332

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