Gastrointestinal (not liver)
Iodamoeba bütschlii

Topic Completed: 1 October 2018

Minor changes: 3 March 2020

Revised: 5 February 2019

Copyright: (c) 2018-2020,, Inc.

PubMed Search: Iodamoeba bütschlii

Nat Pernick, M.D.
Page views in 2019: 1,485
Page views in 2020 to date: 1,080
Cite this page: Pernick N. Iodamoeba bütschlii. website. Accessed August 11th, 2020.
Definition / general
  • Nonpathogenic ameba that can colonize the large intestine
  • The name Iodamoeba comes from the large clear space in the cytoplasm
  • Acquired by ingesting contaminated food or water
  • Does not appear to be associated with HIV infection
Case reports
Cytology description
Cytology images

Contributed by Bobbi Pritt, M.D.

Anal Pap smear

Case of the Week #402

Anal Pap smear

Differential diagnosis
  • Entamoeba histolytica: similar size but its cytoplasm often contains ingested red blood cells and its nucleus has a smaller karyosome with a peripheral rim of condensed chromatin
  • Endolimax nana and other nonpathogenic amebae: may be difficult to differentiate from I. bütschlii; requires a stool examination in the microbiology lab; nonpathogenic amebae can travel with pathogenic organisms (Diagn Cytopathol 2014;42:775)
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