Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 16 February 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Rare and life threatening condition of vascular calcification, first described in 1962, that causes ischemic damage to skin (usually lower extremity) and other organs (G Ital Nefrol 2012;29:674, Hum Pathol 1995;26:1055)
● Also known as calcific uremic arteriopathy (CUA), calcifying panniculitis, vascular calcification-cutaneous necrosis syndrome
● Affects 1-4% of dialysis patients; associated with primary, secondary or tertiary hyperparathyroidism
● 60-80% mortality
● Bilateral, symmetrical, superficial skin lesions with persistence of dorsal pulses; confirm with biopsy
● 69 year old woman with primary hyperparathyroidism due to parathyroid adenoma (Arch Pathol Lab Med 2001;125:1351)
● 70 year old man with end-stage renal failure secondary to IgA nephropathy (J Med Case Rep 2009;3:9297)
Well-demarcated and gangrenous lesion of right leg
Subcutaneous tissue with calcification
Calcification in medium-sized arteries in subcutaneous fat
End of Parathyroid gland > Hyperparathyroidism > Calciphylaxis
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