Parathyroid gland
Hyperparathyroidism
Calciphylaxis

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 11 April 2018, last major update January 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Calciphylaxis[TI] parathyroid

Cite this page: Roychowdhury, M. Calciphylaxis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/parathyroidcalciphylaxis.html. Accessed August 16th, 2018.
Definition / general
  • Rare and life threatening condition of vascular calcification, first described in 1962, that causes ischemic damage to skin (usually lower extremity) and other organs (G Ital Nefrol 2012;29:674, Hum Pathol 1995;26:1055)
  • Also known as calcific uremic arteriopathy (CUA), calcifying panniculitis, vascular calcification-cutaneous necrosis syndrome
  • Affects 1 - 4% of dialysis patients; associated with primary, secondary or tertiary hyperparathyroidism
  • 60 - 80% mortality
Diagnosis
  • Bilateral, symmetrical, superficial skin lesions with persistence of dorsal pulses; confirm with biopsy
Case reports
Treatment
  • Parathyroidectomy
Clinical images

Images hosted on other servers:

Well demarcated
and gangrenous
lesion of right leg

Microscopic (histologic) images

Images hosted on other servers:

Subcutaneous tissue with calcification

Calcification in
medium sized
arteries in
subcutaneous fat