Parathyroid gland

Topic Completed: 1 January 2013

Minor changes: 6 February 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Hypoparathyroidism[TI] pathology full text[sb]

Monika Roychowdhury, M.D.
Page views in 2019: 283
Page views in 2020 to date: 174
Table of Contents
Causes | Symptoms
Cite this page: Roychowdhury M. Hypoparathyroidism. website. Accessed August 14th, 2020.
  • Condition of parathyroid hormone (PTH) deficiency (eMedicine: Hypoparathyroidism [Accessed 11 April 2018])
  • DiGeorge syndrome: complete or partial absence of third and fourth pharyngeal pouches, causing thymic aplasia and T cell deficiency, conotruncal cardiac defects; -22 by FISH
  • Familial: syndrome of chronic mucocutaneous candidiasis, then hypoparathyroidism, then primary adrenal insufficiency
  • Idiopathic atrophy: antibodies directed against calcium sensing receptor in parathyroid gland
  • Radiation
  • Surgery (including thyroidectomy)
  • Cataracts
  • Circumoral numbness or paresthesias of distal extremities
  • Dental abnormalities during early development: dental hypoplasia, failure of eruption, defective enamel and root formation, abraded carious teeth
  • Laryngospasm
  • Prolonged QT interval
  • Seizures
  • Tetany / neuromuscular irritability

Trousseau sign:
  • Carpopedal spasm when inflate blood pressure cuff for several minutes

Chvostek sign:
  • Tap along course of facial nerve to induce contraction of muscles of eye, mouth, nose

Mental status change:
  • Anxiety, depression, confusion, psychosis
  • Movement disorders, papilledema
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