Parathyroid gland - Oxyphil adenoma

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Parathyroid gland

Neoplasms

Oxyphil adenoma

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 17 February 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Composed of 90% or more oxyphil cells, and another parathyroid gland is normal (rules out hyperplasia)
● Usually non-functioning or normal calcium levels
● Rarely functional (Am J Clin Pathol 1982;78:681, Am J Surg Pathol 1989;13:500, Hum Pathol 1984;15:1121)

Case reports
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● 30 year old man with adenoma producing PTHrP with hypercalcemia and normal PTH (World J Surg Oncol 2008;6:24)
● 82 year old woman with functioning adenoma and ureteral stone (Prog Urol 2009;19:636)
● Causing primary hyperparathyroidism and osteitis fibrosa cystica (Indian J Pathol Microbiol 2006;49:448)

Micro description
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● 90%+ oxyphil cells (abundant granular eosinophilic cytoplasm), no atypia

Micro images
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Oxyphil cells at various magnifications

Strong and diffuse expression of PTHrP in the oxyphil adenoma

Electron microscopy description
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● Packed with mitochondria by EM (Am J Clin Pathol 1983;80:878)

End of Parathyroid gland > Neoplasms > Oxyphil adenoma

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