Primary chief cell hyperplasia
Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 16 February 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Parathyromatosis: microscopic foci of hyperplastic parathyroid tissue in neck associated with chief cell hyperplasia and prior surgery
(Hum Pathol 1990;21:234)
● Bilateral primary chief cell hyperplasia associated with loss of APC gene
(Am J Surg Pathol 2002;26:103)
● Excise 3 of 4 glands
● Some surgeons remove all parathyroid tissue
● Can use frozen section, touch prep or intraoperative PTH assay to confirm removal
● Classically, all glands enlarged (up to 10g) vs. pseudoadenomatous (one gland enlarged) vs. occult (all glands normal size but histologically hyperplastic)
● Sheets of chief cells, minimal fat, rare oxyphils
● Usually no rim of normal tissue
Molecular / cytogenetics description
● Increased production of PTH; associated with MEN 1, 2A/2 in 30% of cases (not MEN 2B/3)
● 50% have allelic loss on #11 (where MEN 1 gene is located)
End of Parathyroid gland > Hyperparathyroidism > Primary chief cell hyperplasia
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).