Parathyroid gland - Secondary hyperparathyroidism

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Parathyroid gland

Hyperparathyroidism

Secondary hyperparathyroidism

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 17 February 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Hyperparathyroidism due primarily to non-PTH disease
● Bone changes usually less severe than primary hyperparathyroidism
● Dialysis patients may have discrete, punched-out bone lesions with minimal resorption or osteoblast activity (Am J Surg Pathol 1987;11:205)

Etiology
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● Renal failure (phosphorus retention causes hypocalcemia), inadequate calcium intake, steatorrhea (failure to absorb Vitamin D), vitamin D deficiency or resistance
● All cause hypocalcemia, which causes elevated PTH levels
● Note: high serum phosphate levels DIRECTLY depress serum calcium levels

Gross description
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● Hyperplastic glands, may not be symmetrical

Micro description
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● Similar to primary hyperparathyroidism

Molecular description
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● ~ 60% monoclonal

End of Parathyroid gland > Hyperparathyroidism > Secondary hyperparathyroidism

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