Parathyroid gland
Secondary hyperparathyroidism

Topic Completed: 1 January 2013

Minor changes: 6 February 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Secondary hyperparathyroidism[TI] pathology free full text[sb]

Monika Roychowdhury, M.D.
Page views in 2019: 672
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Cite this page: Roychowdhury M. Secondary hyperparathyroidism. website. Accessed May 28th, 2020.
Definition / general
  • Hyperparathyroidism due primarily to non-PTH disease
  • Bone changes usually less severe than primary hyperparathyroidism
  • Dialysis patients may have discrete, punched out bone lesions with minimal resorption or osteoblast activity (Am J Surg Pathol 1987;11:205)
  • Renal failure (phosphorus retention causes hypocalcemia), inadequate calcium intake, steatorrhea (failure to absorb vitamin D), vitamin D deficiency or resistance
  • All cause hypocalcemia, which causes elevated PTH levels
  • Note: high serum phosphate levels DIRECTLY depress serum calcium levels
Gross description
  • Hyperplastic glands, may not be symmetrical
Microscopic (histologic) description
Molecular / cytogenetics description
  • ~60% monoclonal
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